Ceramide-enriched membrane domains Export

@article{citeulike:3177445, abstract = {Cellular activation involves the re-organization of receptor molecules and the intracellular signalosom in the cell membrane. Recent studies indicate that specialized domains of the cell membrane, termed rafts, are central for the spatial organization of receptors and signaling molecules. Rafts are converted into larger membrane platforms by activity of the acid sphingomyelinase, which hydrolyses raft-sphingomyelin to ceramide. Ceramide molecules spontaneously associate to form ceramide-enriched microdomains, which fuse to large ceramide-enriched membrane platforms. The acid sphingomyelinase is activated by multiple stimuli including CD95, CD40, DR5/TRAIL, CD20, Fc[gamma]RII, CD5, LFA-1, CD28, TNF, the Interleukin-1 receptor, the PAF-receptor, CD14, infection with P. aeruginosa, S. aureus, N. gonorrhoeae, Sindbis-Virus, Rhinovirus, treatment with [gamma]-irradiation, UV-light, doxorubicin, cisplatin, disruption of integrin-signaling and under some conditions of developmental death. Ceramide-enriched membrane platforms serve the clustering of receptors, the recruitment of intracellular signaling molecules and the exclusion of inhibitory signaling factors and, thus, facilitate signal transduction initiated by the specific stimulus.}, author = {Bollinger, Claudia R. and Teichgr\"{a}ber, Volker and Gulbins, Erich}, booktitle = {Lipid Rafts: From Model Membranes to Cells}, citeulike-article-id = {3177445}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.bbamcr.2005.09.001}, citeulike-linkout-1 = {http://www.sciencedirect.com/science/article/B6T20-4H68R59-1/2/f86b23e6df1e895f2291e7e5f2458a7f}, day = {30}, doi = {10.1016/j.bbamcr.2005.09.001}, journal = {Biochimica et Biophysica Acta (BBA) - Molecular Cell Research}, keywords = {ceramide, gonorrhoeae, neisseria, phospholipid, platform, receptor, sphingomyelin}, month = {December}, number = {3}, pages = {284--294}, posted-at = {2008-09-01 05:29:52}, priority = {2}, title = {Ceramide-enriched membrane domains}, url = {http://dx.doi.org/10.1016/j.bbamcr.2005.09.001}, volume = {1746}, year = {2005} }

TY - JOUR ID - citeulike:3177445 L3 - citeulike-article-id:3177445 N2 - Cellular activation involves the re-organization of receptor molecules and the intracellular signalosom in the cell membrane. Recent studies indicate that specialized domains of the cell membrane, termed rafts, are central for the spatial organization of receptors and signaling molecules. Rafts are converted into larger membrane platforms by activity of the acid sphingomyelinase, which hydrolyses raft-sphingomyelin to ceramide. Ceramide molecules spontaneously associate to form ceramide-enriched microdomains, which fuse to large ceramide-enriched membrane platforms. The acid sphingomyelinase is activated by multiple stimuli including CD95, CD40, DR5/TRAIL, CD20, Fc[gamma]RII, CD5, LFA-1, CD28, TNF, the Interleukin-1 receptor, the PAF-receptor, CD14, infection with P. aeruginosa, S. aureus, N. gonorrhoeae, Sindbis-Virus, Rhinovirus, treatment with [gamma]-irradiation, UV-light, doxorubicin, cisplatin, disruption of integrin-signaling and under some conditions of developmental death. Ceramide-enriched membrane platforms serve the clustering of receptors, the recruitment of intracellular signaling molecules and the exclusion of inhibitory signaling factors and, thus, facilitate signal transduction initiated by the specific stimulus. IS - 3 JF - Biochimica et Biophysica Acta (BBA) - Molecular Cell Research EP - 294 TI - Ceramide-enriched membrane domains VL - 1746 T2 - Lipid Rafts: From Model Membranes to Cells SP - 284 KW - ceramide KW - gonorrhoeae KW - neisseria KW - phospholipid KW - platform KW - receptor KW - sphingomyelin AU - Bollinger, Claudia AU - Teichgräber, Volker AU - Gulbins, Erich PY - 2005/12/30/ UR - http://dx.doi.org/10.1016/j.bbamcr.2005.09.001 ER -