Curvature-Dependent Recognition of Ethanolamine Phospholipids by Duramycin and Cinnamycin Export

@article{citeulike:3428130, abstract = {Duramycin is a 19-amino-acid tetracyclic lantibiotic closely related to cinnamycin (Ro09-0198), which is known to bind phosphatidylethanolamine (PE). The lipid specificity of duramycin was not established. The present study indicates that both duramycin and cinnamycin exclusively bind to ethanolamine phospholipids (PE and ethanolamine plasmalogen). Model membrane study indicates that the binding of duramycin and cinnamycin to PE-containing liposomes is dependent on membrane curvature, i.e., the lantibiotics bind small vesicles more efficiently than large liposomes. The binding of the lantibiotics to multilamellar liposomes induces tubulation of membranes, as revealed by electron microscopy and small-angle x-ray scattering. These results suggest that both duramycin and cinnamycin promote their binding to the PE-containing membrane by deforming membrane curvature. 10.1529/biophysj.106.101584}, author = {Iwamoto, Kunihiko and Hayakawa, Tomohiro and Murate, Motohide and Makino, Asami and Ito, Kazuki and Fujisawa, Tetsuro and Kobayashi, Toshihide}, citeulike-article-id = {3428130}, citeulike-linkout-0 = {http://dx.doi.org/10.1529/biophysj.106.101584}, citeulike-linkout-1 = {http://www.biophysj.org/cgi/content/abstract/93/5/1608}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/17483159}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=17483159}, day = {1}, doi = {10.1529/biophysj.106.101584}, journal = {Biophys. J.}, keywords = {ethanolamine, lysophosphatidylethanolamine, phophatidylethanolamine}, month = {September}, number = {5}, pages = {1608--1619}, posted-at = {2008-10-18 19:18:14}, priority = {2}, title = {Curvature-Dependent Recognition of Ethanolamine Phospholipids by Duramycin and Cinnamycin}, url = {http://dx.doi.org/10.1529/biophysj.106.101584}, volume = {93}, year = {2007} }

TY - JOUR ID - citeulike:3428130 L3 - citeulike-article-id:3428130 N2 - Duramycin is a 19-amino-acid tetracyclic lantibiotic closely related to cinnamycin (Ro09-0198), which is known to bind phosphatidylethanolamine (PE). The lipid specificity of duramycin was not established. The present study indicates that both duramycin and cinnamycin exclusively bind to ethanolamine phospholipids (PE and ethanolamine plasmalogen). Model membrane study indicates that the binding of duramycin and cinnamycin to PE-containing liposomes is dependent on membrane curvature, i.e., the lantibiotics bind small vesicles more efficiently than large liposomes. The binding of the lantibiotics to multilamellar liposomes induces tubulation of membranes, as revealed by electron microscopy and small-angle x-ray scattering. These results suggest that both duramycin and cinnamycin promote their binding to the PE-containing membrane by deforming membrane curvature. 10.1529/biophysj.106.101584 IS - 5 JF - Biophys. J. EP - 1619 TI - Curvature-Dependent Recognition of Ethanolamine Phospholipids by Duramycin and Cinnamycin VL - 93 SP - 1608 KW - ethanolamine KW - lysophosphatidylethanolamine KW - phophatidylethanolamine AU - Iwamoto, Kunihiko AU - Hayakawa, Tomohiro AU - Murate, Motohide AU - Makino, Asami AU - Ito, Kazuki AU - Fujisawa, Tetsuro AU - Kobayashi, Toshihide PY - 2007/09/01/ UR - http://dx.doi.org/10.1529/biophysj.106.101584 ER -