Nanoparticle-mediated drug delivery to tumor vasculature suppresses metastasis Export

@article{citeulike:3125383, abstract = {10.1073/pnas.0803728105 Integrin ανβ3 is found on a subset of tumor blood vessels where it is associated with angiogenesis and malignant tumor growth. We designed an ανβ3-targeted nanoparticle (NP) encapsulating the cytotoxic drug doxorubicin (Dox) for targeted drug delivery to the ανβ3-expressing tumor vasculature. We observed real-time targeting of this NP to tumor vessels and noted selective apoptosis in regions of the ανβ3-expressing tumor vasculature. In clinically relevant pancreatic and renal cell orthotopic models of spontaneous metastasis, targeted delivery of Dox produced an antimetastatic effect. In fact, ανβ3-mediated delivery of this drug to the tumor vasculature resulted in a 15-fold increase in antimetastatic activity without producing drug-associated weight loss as observed with systemic administration of the free drug. These findings reveal that NP-based delivery of cytotoxic drugs to the ανβ3-positive tumor vasculature represents an approach for treating metastatic disease.}, author = {Murphy, Eric A. and Majeti, Bharat K. and Barnes, Leo A. and Makale, Milan and Weis, Sara M. and Lutu-Fuga, Kimberly and Wrasidlo, Wolfgang and Cheresh, David A.}, citeulike-article-id = {3125383}, citeulike-linkout-0 = {http://dx.doi.org/10.1073/pnas.0803728105}, citeulike-linkout-1 = {http://www.pnas.org/content/105/27/9343.abstract}, citeulike-linkout-2 = {http://www.pnas.org/content/105/27/9343.full.pdf}, citeulike-linkout-3 = {http://view.ncbi.nlm.nih.gov/pubmed/18607000}, citeulike-linkout-4 = {http://www.hubmed.org/display.cgi?uids=18607000}, doi = {10.1073/pnas.0803728105}, journal = {Proceedings of the National Academy of Sciences}, keywords = {nanoparticulas}, month = {July}, number = {27}, pages = {9343--9348}, posted-at = {2008-08-15 10:30:31}, priority = {3}, title = {Nanoparticle-mediated drug delivery to tumor vasculature suppresses metastasis}, url = {http://dx.doi.org/10.1073/pnas.0803728105}, volume = {105}, year = {2008} }

TY - JOUR ID - citeulike:3125383 L3 - citeulike-article-id:3125383 N2 - 10.1073/pnas.0803728105 Integrin ανβ3 is found on a subset of tumor blood vessels where it is associated with angiogenesis and malignant tumor growth. We designed an ανβ3-targeted nanoparticle (NP) encapsulating the cytotoxic drug doxorubicin (Dox) for targeted drug delivery to the ανβ3-expressing tumor vasculature. We observed real-time targeting of this NP to tumor vessels and noted selective apoptosis in regions of the ανβ3-expressing tumor vasculature. In clinically relevant pancreatic and renal cell orthotopic models of spontaneous metastasis, targeted delivery of Dox produced an antimetastatic effect. In fact, ανβ3-mediated delivery of this drug to the tumor vasculature resulted in a 15-fold increase in antimetastatic activity without producing drug-associated weight loss as observed with systemic administration of the free drug. These findings reveal that NP-based delivery of cytotoxic drugs to the ανβ3-positive tumor vasculature represents an approach for treating metastatic disease. IS - 27 JF - Proceedings of the National Academy of Sciences EP - 9348 TI - Nanoparticle-mediated drug delivery to tumor vasculature suppresses metastasis VL - 105 SP - 9343 KW - nanoparticulas AU - Murphy, Eric AU - Majeti, Bharat AU - Barnes, Leo AU - Makale, Milan AU - Weis, Sara AU - Lutu-Fuga, Kimberly AU - Wrasidlo, Wolfgang AU - Cheresh, David PY - 2008/07// UR - http://dx.doi.org/10.1073/pnas.0803728105 ER -