Neural generators of brain potentials before rapid eye movements during human REM sleep: A study using sLORETA Export

@article{citeulike:3125451, abstract = {Objective Brain activity preceding rapid eye movements (REM) during human REM sleep has remained poorly understood. Slow negative brain potential (pre-REM negativity) appears before REMs. Current sources of this potential were investigated to identify brain activity immediately preceding REMs.Methods In this study, 22 young healthy volunteers (20-25 years old) participated. Polysomnograms were recorded during normal nocturnal sleep. Brain potentials between 200 ms before and 50 ms after the onset of REMs and pseudo-triggers (3000 ms before the onset of REMs) were averaged. Standardized low-resolution brain electromagnetic tomography (sLORETA) was used to estimate current sources of pre-REM negativity.Results Pre-REM negativity appeared with the maximal amplitude at right prefrontal sites immediately before REMs. However, this negativity did not appear before pseudo-triggers. Current sources of the pre-REM negativity were estimated in the ventromedial prefrontal cortex, uncus, insula, anterior cingulated cortex, basal forebrain, parahippocampal gyrus, premotor cortex and frontal eye field.Conclusions The pre-REM negativity reflects brain activity coupled with the occurrence of REMs. Results of this study suggest that emotion, memory, and motor-related brain activity might occur before REMs.Significance Pre-REM negativity is expected to be a psychophysiological index for elucidating functions of REM sleep.}, author = {Abe, Takashi and Ogawa, Keiko and Nittono, Hiroshi and Hori, Tadao}, citeulike-article-id = {3125451}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.clinph.2008.05.008}, citeulike-linkout-1 = {http://www.sciencedirect.com/science/article/B6VNP-4SYKM37-5/2/24e9712a4dc699c287ad4bdd47e78b93}, doi = {10.1016/j.clinph.2008.05.008}, journal = {Clinical Neurophysiology}, keywords = {loreta, rem, sueo}, month = {September}, number = {9}, pages = {2044--2053}, posted-at = {2008-08-15 11:10:58}, priority = {2}, title = {Neural generators of brain potentials before rapid eye movements during human REM sleep: A study using sLORETA}, url = {http://dx.doi.org/10.1016/j.clinph.2008.05.008}, volume = {119}, year = {2008} }

TY - JOUR ID - citeulike:3125451 L3 - citeulike-article-id:3125451 N2 - Objective Brain activity preceding rapid eye movements (REM) during human REM sleep has remained poorly understood. Slow negative brain potential (pre-REM negativity) appears before REMs. Current sources of this potential were investigated to identify brain activity immediately preceding REMs.Methods In this study, 22 young healthy volunteers (20-25 years old) participated. Polysomnograms were recorded during normal nocturnal sleep. Brain potentials between 200 ms before and 50 ms after the onset of REMs and pseudo-triggers (3000 ms before the onset of REMs) were averaged. Standardized low-resolution brain electromagnetic tomography (sLORETA) was used to estimate current sources of pre-REM negativity.Results Pre-REM negativity appeared with the maximal amplitude at right prefrontal sites immediately before REMs. However, this negativity did not appear before pseudo-triggers. Current sources of the pre-REM negativity were estimated in the ventromedial prefrontal cortex, uncus, insula, anterior cingulated cortex, basal forebrain, parahippocampal gyrus, premotor cortex and frontal eye field.Conclusions The pre-REM negativity reflects brain activity coupled with the occurrence of REMs. Results of this study suggest that emotion, memory, and motor-related brain activity might occur before REMs.Significance Pre-REM negativity is expected to be a psychophysiological index for elucidating functions of REM sleep. IS - 9 JF - Clinical Neurophysiology EP - 2053 TI - Neural generators of brain potentials before rapid eye movements during human REM sleep: A study using sLORETA VL - 119 SP - 2044 KW - loreta KW - rem KW - sueo AU - Abe, Takashi AU - Ogawa, Keiko AU - Nittono, Hiroshi AU - Hori, Tadao PY - 2008/09// UR - http://dx.doi.org/10.1016/j.clinph.2008.05.008 ER -