ChIPping away at gene regulation.

by: CE Massie, IG Mills

EMBO reports, Vol. 9, No. 4. (April 2008), pp. 337-343.

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Abstract

The coordinated regulation of gene expression in higher eukaryotes is complex and poorly understood. Recent technological advances have allowed the first insights into these networks on a genome-wide scale. These investigations have identified transcription factor target sites in the genome and successfully predicted cooperative interactions with other factors. However, a detailed understanding of the processes that coordinate gene expression remains elusive. Here, we highlight the advances that have been made using current methods, and the need for new technologies to address the gaps in our knowledge and to map these complex pathways further.

@article{citeulike:2972079, abstract = {The coordinated regulation of gene expression in higher eukaryotes is complex and poorly understood. Recent technological advances have allowed the first insights into these networks on a genome-wide scale. These investigations have identified transcription factor target sites in the genome and successfully predicted cooperative interactions with other factors. However, a detailed understanding of the processes that coordinate gene expression remains elusive. Here, we highlight the advances that have been made using current methods, and the need for new technologies to address the gaps in our knowledge and to map these complex pathways further.}, address = {Uro-Oncology Research Group, CRUK Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK.}, author = {Massie, C. E. and Mills, I. G. }, citeulike-article-id = {2972079}, doi = {10.1038/embor.2008.44}, issn = {1469-221X}, journal = {EMBO reports}, keywords = {chip-chip, chip-on-chip, review}, month = {April}, number = {4}, pages = {337--343}, posted-at = {2008-07-08 10:53:50}, priority = {3}, title = {ChIPping away at gene regulation.}, url = {http://dx.doi.org/10.1038/embor.2008.44}, volume = {9}, year = {2008} }

RIS record

TY - JOUR ID - citeulike:2972079 L3 - citeulike-article-id:2972079 TI - ChIPping away at gene regulation. JF - EMBO reports VL - 9 IS - 4 SP - 337 EP - 343 AD - Uro-Oncology Research Group, CRUK Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK. SN - 1469-221X N2 - The coordinated regulation of gene expression in higher eukaryotes is complex and poorly understood. Recent technological advances have allowed the first insights into these networks on a genome-wide scale. These investigations have identified transcription factor target sites in the genome and successfully predicted cooperative interactions with other factors. However, a detailed understanding of the processes that coordinate gene expression remains elusive. Here, we highlight the advances that have been made using current methods, and the need for new technologies to address the gaps in our knowledge and to map these complex pathways further. KW - chip-chip KW - chip-on-chip KW - review AU - Massie, CE AU - Mills, IG PY - 2008/04// UR - http://dx.doi.org/10.1038/embor.2008.44 ER -

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