Eye position and memory saccade related responses in substantia nigra pars reticulata. Export

@article{citeulike:100347, abstract = {The substantia nigra pars reticulata (SNr), a major output nucleus of the basal ganglia, has been implicated anatomically, pharmacologically and physiologically in the generation of saccadic eye movements. However, the unique contribution of the SNr to saccade generation remains elusive. We studied the activity of SNr neurons while rhesus monkeys made saccades from different initial orbital positions, to determine what effects, if any, eye position had on SNr neuronal activity. We found that there was no effect of eye position on SNr neuronal responses. We also examined the responses of SNr neurons during memory-guided saccades to determine whether SNr discharges were affected by whether the target of the upcoming saccade was visible. We found that there was no change in response properties during memory saccade trials as compared to otherwise identical visually guided trials. SNr neurons appear to carry no information about either eye position or whether a movement is guided by a visible or remembered target. These results suggest that nigral signals are encoded in the same coordinate frame as those in the SC and FEF, but that unlike neuronal responses in these areas, SNr activity is not influenced by whether the saccade target remains visible until the movement is executed.}, address = {Center for Neural Science, New York University, 4 Washington Place, Room 809, NY 10003, New York, USA. hannah@cns.nyu.edu}, author = {Bayer, H. M. and Handel, A. and Glimcher, P. W.}, citeulike-article-id = {100347}, citeulike-linkout-0 = {http://dx.doi.org/10.1007/s00221-003-1735-7}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/14726989}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=14726989}, doi = {10.1007/s00221-003-1735-7}, issn = {0014-4819}, journal = {Exp Brain Res}, keywords = {basal-ganglia, electrophysiology, eye-movement}, month = {February}, number = {4}, pages = {428--441}, posted-at = {2005-03-23 23:51:57}, priority = {4}, title = {Eye position and memory saccade related responses in substantia nigra pars reticulata.}, url = {http://dx.doi.org/10.1007/s00221-003-1735-7}, volume = {154}, year = {2004} }

TY - JOUR ID - citeulike:100347 L3 - citeulike-article-id:100347 N2 - The substantia nigra pars reticulata (SNr), a major output nucleus of the basal ganglia, has been implicated anatomically, pharmacologically and physiologically in the generation of saccadic eye movements. However, the unique contribution of the SNr to saccade generation remains elusive. We studied the activity of SNr neurons while rhesus monkeys made saccades from different initial orbital positions, to determine what effects, if any, eye position had on SNr neuronal activity. We found that there was no effect of eye position on SNr neuronal responses. We also examined the responses of SNr neurons during memory-guided saccades to determine whether SNr discharges were affected by whether the target of the upcoming saccade was visible. We found that there was no change in response properties during memory saccade trials as compared to otherwise identical visually guided trials. SNr neurons appear to carry no information about either eye position or whether a movement is guided by a visible or remembered target. These results suggest that nigral signals are encoded in the same coordinate frame as those in the SC and FEF, but that unlike neuronal responses in these areas, SNr activity is not influenced by whether the saccade target remains visible until the movement is executed. IS - 4 JF - Exp Brain Res SN - 0014-4819 AD - Center for Neural Science, New York University, 4 Washington Place, Room 809, NY 10003, New York, USA. hannah@cns.nyu.edu EP - 441 TI - Eye position and memory saccade related responses in substantia nigra pars reticulata. VL - 154 SP - 428 KW - basal-ganglia KW - electrophysiology KW - eye-movement AU - Bayer, HM AU - Handel, A AU - Glimcher, PW PY - 2004/02// UR - http://dx.doi.org/10.1007/s00221-003-1735-7 ER -