Working memory, response selection, and effortful processing in rats with medial prefrontal lesions. Export

@article{citeulike:305951, abstract = {This study examined the effects of lesions of the prelimbic area of the rat prefrontal cortex on acquisition and retention of nonmatching (NMTS) and matching-to-sample (MTS) tasks. Both tasks involved a reference and a working memory component, but only working memory was impaired by the lesions. A comparison of the 2 tasks revealed quantitatively similar deficits in postoperatively trained rats. In preoperatively trained rats, however, the deficits were more important in the MTS task than in the NMTS task. In addition, an effect of interference between successive trials was observed in the NMTS task but not in the MTS task. Perseverative tendencies were observed in the MTS task only. These results suggest that prefrontal lesions induce working memory deficits as a result of poor temporal encoding and increased susceptibility to interference and impair effortful processing, such as that engaged in response selection mechanisms.}, address = {Laboratoire de Neurosciences Cognitives, Centre National de la Recherche Scientifique, Marseille, France.}, author = {Granon, S. and Vidal, C. and Thinus-Blanc, C. and Changeux, J. P. and Poucet, B.}, citeulike-article-id = {305951}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/7826511}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=7826511}, issn = {0735-7044}, journal = {Behav Neurosci}, keywords = {decision-making, mpfc, rat}, month = {October}, number = {5}, pages = {883--891}, posted-at = {2005-08-28 22:13:01}, priority = {3}, title = {Working memory, response selection, and effortful processing in rats with medial prefrontal lesions.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/7826511}, volume = {108}, year = {1994} }

TY - JOUR ID - citeulike:305951 L3 - citeulike-article-id:305951 N2 - This study examined the effects of lesions of the prelimbic area of the rat prefrontal cortex on acquisition and retention of nonmatching (NMTS) and matching-to-sample (MTS) tasks. Both tasks involved a reference and a working memory component, but only working memory was impaired by the lesions. A comparison of the 2 tasks revealed quantitatively similar deficits in postoperatively trained rats. In preoperatively trained rats, however, the deficits were more important in the MTS task than in the NMTS task. In addition, an effect of interference between successive trials was observed in the NMTS task but not in the MTS task. Perseverative tendencies were observed in the MTS task only. These results suggest that prefrontal lesions induce working memory deficits as a result of poor temporal encoding and increased susceptibility to interference and impair effortful processing, such as that engaged in response selection mechanisms. IS - 5 JF - Behav Neurosci SN - 0735-7044 AD - Laboratoire de Neurosciences Cognitives, Centre National de la Recherche Scientifique, Marseille, France. EP - 891 TI - Working memory, response selection, and effortful processing in rats with medial prefrontal lesions. VL - 108 SP - 883 KW - decision-making KW - mpfc KW - rat AU - Granon, S AU - Vidal, C AU - Thinus-Blanc, C AU - Changeux, JP AU - Poucet, B PY - 1994/10// UR - http://view.ncbi.nlm.nih.gov/pubmed/7826511 ER -