Role of axonal transport in neurodegenerative diseases. Export

@article{citeulike:4991171, abstract = {Many major human neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS), display axonal pathologies including abnormal accumulations of proteins and organelles. Such pathologies highlight damage to the axon as part of the pathogenic process and, in particular, damage to transport of cargoes through axons. Indeed, we now know that disruption of axonal transport is an early and perhaps causative event in many of these diseases. Here, we review the role of axonal transport in neurodegenerative disease.}, author = {De Vos, Kurt J. and Grierson, Andrew J. and Ackerley, Steven and Miller, Christopher C.}, citeulike-article-id = {4991171}, citeulike-linkout-0 = {http://arjournals.annualreviews.org/doi/abs/10.1146/annurev.neuro.31.061307.090711}, citeulike-linkout-1 = {http://dx.doi.org/10.1146/annurev.neuro.31.061307.090711}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/18558852}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=18558852}, doi = {10.1146/annurev.neuro.31.061307.090711}, issn = {0147-006X}, journal = {Annual review of neuroscience}, keywords = {axonaltransport, neurodegeneration, review}, number = {1}, pages = {151--173}, posted-at = {2009-06-27 19:32:30}, priority = {2}, title = {Role of axonal transport in neurodegenerative diseases.}, url = {http://dx.doi.org/10.1146/annurev.neuro.31.061307.090711}, volume = {31}, year = {2008} }

TY - JOUR ID - citeulike:4991171 L3 - citeulike-article-id:4991171 N2 - Many major human neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS), display axonal pathologies including abnormal accumulations of proteins and organelles. Such pathologies highlight damage to the axon as part of the pathogenic process and, in particular, damage to transport of cargoes through axons. Indeed, we now know that disruption of axonal transport is an early and perhaps causative event in many of these diseases. Here, we review the role of axonal transport in neurodegenerative disease. IS - 1 JF - Annual review of neuroscience SN - 0147-006X EP - 173 TI - Role of axonal transport in neurodegenerative diseases. VL - 31 SP - 151 KW - axonaltransport KW - neurodegeneration KW - review AU - De Vos, Kurt AU - Grierson, Andrew AU - Ackerley, Steven AU - Miller, Christopher PY - 2008/// UR - http://dx.doi.org/10.1146/annurev.neuro.31.061307.090711 ER -