Genetics of motor neuron disorders: new insights into pathogenic mechanisms Export

@article{citeulike:5977249, abstract = {The past few years have seen the identification of dozens of genes with causal roles in motor neuron diseases (MNDs), particularly for amyotrophic lateral sclerosis and hereditary spastic paraplegia. Although many additional MND genes remain to be identified, the accumulated genetic evidence has already provided new insights into MND pathogenesis, which adds to the well-established involvement of superoxide dismutase 1 (SOD1) mutations. The pathways that have been recently implicated include those that affect RNA processing, axonal transport and mitochondrial function. The functional classes of MND genes identified so far are likely to aid the selection of high-priority candidate genes for future investigation, including those for so-called sporadic cases.}, author = {Dion, Patrick A. and Daoud, Hussein and Rouleau, Guy A.}, citeulike-article-id = {5977249}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nrg2680}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nrg2680}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19823194}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19823194}, day = {13}, doi = {10.1038/nrg2680}, issn = {1471-0056}, journal = {Nature Reviews Genetics}, keywords = {als, genetics, mnd, motoneuron, review}, month = {October}, number = {11}, pages = {769--782}, posted-at = {2009-10-25 20:16:14}, priority = {2}, publisher = {Nature Publishing Group}, title = {Genetics of motor neuron disorders: new insights into pathogenic mechanisms}, url = {http://dx.doi.org/10.1038/nrg2680}, volume = {10}, year = {2009} }

TY - JOUR ID - citeulike:5977249 L3 - citeulike-article-id:5977249 N2 - The past few years have seen the identification of dozens of genes with causal roles in motor neuron diseases (MNDs), particularly for amyotrophic lateral sclerosis and hereditary spastic paraplegia. Although many additional MND genes remain to be identified, the accumulated genetic evidence has already provided new insights into MND pathogenesis, which adds to the well-established involvement of superoxide dismutase 1 (SOD1) mutations. The pathways that have been recently implicated include those that affect RNA processing, axonal transport and mitochondrial function. The functional classes of MND genes identified so far are likely to aid the selection of high-priority candidate genes for future investigation, including those for so-called sporadic cases. IS - 11 JF - Nature Reviews Genetics SN - 1471-0056 EP - 782 TI - Genetics of motor neuron disorders: new insights into pathogenic mechanisms PB - Nature Publishing Group VL - 10 SP - 769 KW - als KW - genetics KW - mnd KW - motoneuron KW - review AU - Dion, Patrick AU - Daoud, Hussein AU - Rouleau, Guy PY - 2009/10/13/ UR - http://dx.doi.org/10.1038/nrg2680 ER -