Androgen receptor and Kennedy disease/spinal bulbar muscular atrophy. Export

@article{citeulike:6051419, abstract = {Kennedy Disease/Spinal Bulbar Muscular Atrophy (KD/SBMA) is a progressive neurodegenerative disease caused by genetic polyglutamine expansion of the androgen receptor. We have recently found that overexpression of wildtype androgen receptor in skeletal muscle of transgenic mice results in a KD/SBMA phenotype. This surprising result challenges the orthodox view that KD/SBMA requires expression of polyglutamine expanded androgen receptor within motoneurons. Theories relating to the etiology of this disease drawn from studies of human patients, cellular and mouse models are considered with a special emphasis on potential myogenic contributions to as well as the molecular etiology of KD/SBMA.}, author = {Monks, Douglas Ashley A. and Rao, Pengcheng and Mo, Kaiguo and Johansen, Jamie Ann A. and Lewis, Gareth and Kemp, Michael Quentin Q.}, citeulike-article-id = {6051419}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.yhbeh.2007.12.009}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18321505}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18321505}, doi = {10.1016/j.yhbeh.2007.12.009}, issn = {0018-506X}, journal = {Hormones and behavior}, keywords = {ar, review, sbma}, month = {May}, number = {5}, pages = {729--740}, posted-at = {2009-10-31 20:13:54}, priority = {2}, title = {Androgen receptor and Kennedy disease/spinal bulbar muscular atrophy.}, url = {http://dx.doi.org/10.1016/j.yhbeh.2007.12.009}, volume = {53}, year = {2008} }

TY - JOUR ID - citeulike:6051419 L3 - citeulike-article-id:6051419 N2 - Kennedy Disease/Spinal Bulbar Muscular Atrophy (KD/SBMA) is a progressive neurodegenerative disease caused by genetic polyglutamine expansion of the androgen receptor. We have recently found that overexpression of wildtype androgen receptor in skeletal muscle of transgenic mice results in a KD/SBMA phenotype. This surprising result challenges the orthodox view that KD/SBMA requires expression of polyglutamine expanded androgen receptor within motoneurons. Theories relating to the etiology of this disease drawn from studies of human patients, cellular and mouse models are considered with a special emphasis on potential myogenic contributions to as well as the molecular etiology of KD/SBMA. IS - 5 JF - Hormones and behavior SN - 0018-506X EP - 740 TI - Androgen receptor and Kennedy disease/spinal bulbar muscular atrophy. VL - 53 SP - 729 KW - ar KW - review KW - sbma AU - Monks, Douglas Ashley AU - Rao, Pengcheng AU - Mo, Kaiguo AU - Johansen, Jamie Ann AU - Lewis, Gareth AU - Kemp, Michael Quentin PY - 2008/05// UR - http://dx.doi.org/10.1016/j.yhbeh.2007.12.009 ER -