Epigenetic stem cell signature in cancer. Export

@article{citeulike:1027610, abstract = {Embryonic stem cells rely on Polycomb group proteins to reversibly repress genes required for differentiation. We report that stem cell Polycomb group targets are up to 12-fold more likely to have cancer-specific promoter DNA hypermethylation than non-targets, supporting a stem cell origin of cancer in which reversible gene repression is replaced by permanent silencing, locking the cell into a perpetual state of self-renewal and thereby predisposing to subsequent malignant transformation.}, address = {Department of Gynecological Oncology, Institute for Women's Health, University College London, London WC1E 6DH, UK.}, author = {Widschwendter, Martin and Fiegl, Heidi and Egle, Daniel and Mueller-Holzner, Elisabeth and Spizzo, Gilbert and Marth, Christian and Weisenberger, Daniel J J. and Campan, Mihaela and Young, Joanne and Jacobs, Ian and Laird, Peter W W.}, citeulike-article-id = {1027610}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/ng1941}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/ng1941}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/17200673}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=17200673}, day = {31}, doi = {10.1038/ng1941}, issn = {1061-4036}, journal = {Nat Genet}, keywords = {cancer, methylation}, month = {December}, posted-at = {2009-05-11 18:33:02}, priority = {2}, title = {Epigenetic stem cell signature in cancer.}, url = {http://dx.doi.org/10.1038/ng1941}, year = {2006} }

TY - JOUR ID - citeulike:1027610 L3 - citeulike-article-id:1027610 N2 - Embryonic stem cells rely on Polycomb group proteins to reversibly repress genes required for differentiation. We report that stem cell Polycomb group targets are up to 12-fold more likely to have cancer-specific promoter DNA hypermethylation than non-targets, supporting a stem cell origin of cancer in which reversible gene repression is replaced by permanent silencing, locking the cell into a perpetual state of self-renewal and thereby predisposing to subsequent malignant transformation. JF - Nat Genet SN - 1061-4036 AD - Department of Gynecological Oncology, Institute for Women's Health, University College London, London WC1E 6DH, UK. TI - Epigenetic stem cell signature in cancer. KW - cancer KW - methylation AU - Widschwendter, Martin AU - Fiegl, Heidi AU - Egle, Daniel AU - Mueller-Holzner, Elisabeth AU - Spizzo, Gilbert AU - Marth, Christian AU - Weisenberger, Daniel J AU - Campan, Mihaela AU - Young, Joanne AU - Jacobs, Ian AU - Laird, Peter W PY - 2006/12/31/ UR - http://dx.doi.org/10.1038/ng1941 ER -