Silencing by imprinted noncoding RNAs: is transcription the answer? Export

@article{citeulike:3893638, abstract = {Non-coding RNAs (ncRNAs) with gene regulatory functions are starting to be seen as a common feature of mammalian gene regulation with the discovery that most of the transcriptome is ncRNA. The prototype has long been the Xist ncRNA, which induces X-chromosome inactivation in female cells. However, a new paradigm is emerging--the silencing of imprinted gene clusters by long ncRNAs. Here, we review models by which imprinted ncRNAs could function. We argue that an Xist-like model is only one of many possible solutions and that imprinted ncRNAs could provide the better model for understanding the function of the new class of ncRNAs associated with non-imprinted mammalian genes.}, author = {Pauler, F. M. and Koerner, M. V. and Barlow, D. P.}, citeulike-article-id = {3893638}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.tig.2007.03.018}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S0168952507001217}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/17445943}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=17445943}, doi = {10.1016/j.tig.2007.03.018}, issn = {0168-9525}, journal = {Trends in genetics : TIG}, keywords = {imprinted-genes, noncoding-rna}, month = {June}, number = {6}, pages = {284--292}, posted-at = {2009-04-18 18:50:31}, priority = {2}, title = {Silencing by imprinted noncoding RNAs: is transcription the answer?}, url = {http://dx.doi.org/10.1016/j.tig.2007.03.018}, volume = {23}, year = {2007} }

TY - JOUR ID - citeulike:3893638 L3 - citeulike-article-id:3893638 N2 - Non-coding RNAs (ncRNAs) with gene regulatory functions are starting to be seen as a common feature of mammalian gene regulation with the discovery that most of the transcriptome is ncRNA. The prototype has long been the Xist ncRNA, which induces X-chromosome inactivation in female cells. However, a new paradigm is emerging--the silencing of imprinted gene clusters by long ncRNAs. Here, we review models by which imprinted ncRNAs could function. We argue that an Xist-like model is only one of many possible solutions and that imprinted ncRNAs could provide the better model for understanding the function of the new class of ncRNAs associated with non-imprinted mammalian genes. IS - 6 JF - Trends in genetics : TIG SN - 0168-9525 EP - 292 TI - Silencing by imprinted noncoding RNAs: is transcription the answer? VL - 23 SP - 284 KW - imprinted-genes KW - noncoding-rna AU - Pauler, FM AU - Koerner, MV AU - Barlow, DP PY - 2007/06// UR - http://dx.doi.org/10.1016/j.tig.2007.03.018 ER -