Tiny RNAs associated with transcription start sites in animals. Export

@article{citeulike:4375814, abstract = {It has been reported that relatively short RNAs of heterogeneous sizes are derived from sequences near the promoters of eukaryotic genes. In conjunction with the FANTOM4 project, we have identified tiny RNAs with a modal length of 18 nt that map within -60 to +120 nt of transcription start sites (TSSs) in human, chicken and Drosophila. These transcription initiation RNAs (tiRNAs) are derived from sequences on the same strand as the TSS and are preferentially associated with G+C-rich promoters. The 5' ends of tiRNAs show peak density 10-30 nt downstream of TSSs, indicating that they are processed. tiRNAs are generally, although not exclusively, associated with highly expressed transcripts and sites of RNA polymerase II binding. We suggest that tiRNAs may be a general feature of transcription in metazoa and possibly all eukaryotes.}, author = {Taft, Ryan J. and Glazov, Evgeny A. and Cloonan, Nicole and Simons, Cas and Stephen, Stuart and Faulkner, Geoffrey J. and Lassmann, Timo and Forrest, Alistair R. and Grimmond, Sean M. and Schroder, Kate and Irvine, Katharine and Arakawa, Takahiro and Nakamura, Mari and Kubosaki, Atsutaka and Hayashida, Kengo and Kawazu, Chika and Murata, Mitsuyoshi and Nishiyori, Hiromi and Fukuda, Shiro and Kawai, Jun and Daub, Carsten O. and Hume, David A. and Suzuki, Harukazu and Orlando, Valerio and Carninci, Piero and Hayashizaki, Yoshihide and Mattick, John S.}, citeulike-article-id = {4375814}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/ng.312}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/ng.312}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19377478}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19377478}, day = {19}, doi = {10.1038/ng.312}, issn = {1546-1718}, journal = {Nature genetics}, keywords = {chromatin-organization, noncoding-rna, polymerase}, month = {May}, number = {5}, pages = {572--578}, posted-at = {2009-10-03 01:21:21}, priority = {5}, publisher = {Nature Publishing Group}, title = {Tiny RNAs associated with transcription start sites in animals.}, url = {http://dx.doi.org/10.1038/ng.312}, volume = {41}, year = {2009} }

TY - JOUR ID - citeulike:4375814 L3 - citeulike-article-id:4375814 N2 - It has been reported that relatively short RNAs of heterogeneous sizes are derived from sequences near the promoters of eukaryotic genes. In conjunction with the FANTOM4 project, we have identified tiny RNAs with a modal length of 18 nt that map within -60 to +120 nt of transcription start sites (TSSs) in human, chicken and Drosophila. These transcription initiation RNAs (tiRNAs) are derived from sequences on the same strand as the TSS and are preferentially associated with G+C-rich promoters. The 5' ends of tiRNAs show peak density 10-30 nt downstream of TSSs, indicating that they are processed. tiRNAs are generally, although not exclusively, associated with highly expressed transcripts and sites of RNA polymerase II binding. We suggest that tiRNAs may be a general feature of transcription in metazoa and possibly all eukaryotes. IS - 5 JF - Nature genetics SN - 1546-1718 EP - 578 TI - Tiny RNAs associated with transcription start sites in animals. PB - Nature Publishing Group VL - 41 SP - 572 KW - chromatin-organization KW - noncoding-rna KW - polymerase AU - Taft, Ryan AU - Glazov, Evgeny AU - Cloonan, Nicole AU - Simons, Cas AU - Stephen, Stuart AU - Faulkner, Geoffrey AU - Lassmann, Timo AU - Forrest, Alistair AU - Grimmond, Sean AU - Schroder, Kate AU - Irvine, Katharine AU - Arakawa, Takahiro AU - Nakamura, Mari AU - Kubosaki, Atsutaka AU - Hayashida, Kengo AU - Kawazu, Chika AU - Murata, Mitsuyoshi AU - Nishiyori, Hiromi AU - Fukuda, Shiro AU - Kawai, Jun AU - Daub, Carsten AU - Hume, David AU - Suzuki, Harukazu AU - Orlando, Valerio AU - Carninci, Piero AU - Hayashizaki, Yoshihide AU - Mattick, John PY - 2009/05/19/ UR - http://dx.doi.org/10.1038/ng.312 ER -