A Unifying Model for the Selective Regulation of Inducible Transcription by CpG Islands and Nucleosome Remodeling Export

@article{citeulike:5160460, abstract = {We describe a broad mechanistic framework for the transcriptional induction of mammalian primary response genes by Toll-like receptors and other stimuli. One major class of primary response genes is characterized by CpG-island promoters, which facilitate promiscuous induction from constitutively active chromatin without a requirement for SWI/SNF nucleosome remodeling complexes. The low nucleosome occupancy at promoters in this class can be attributed to the assembly of CpG islands into unstable nucleosomes, which may lead to SWI/SNF independence. Another major class consists of non-CpG-island promoters that assemble into stable nucleosomes, resulting in SWI/SNF dependence and a requirement for transcription factors that promote selective nucleosome remodeling. Some stimuli, including serum and tumor necrosis factor-±, exhibit a strong bias toward activation of SWI/SNF-independent CpG-island genes. In contrast, interferon-² is strongly biased toward SWI/SNF-dependent non-CpG-island genes. By activating a diverse set of transcription factors, Toll-like receptors induce both classes and others for an optimal response to microbial pathogens.}, author = {Ramirez-Carrozzi, Vladimir R. and Braas, Daniel and Bhatt, Dev M. and Cheng, Christine S. and Hong, Christine and Doty, Kevin R. and Black, Joshua C. and Hoffmann, Alexander and Carey, Michael and Smale, Stephen T.}, citeulike-article-id = {5160460}, citeulike-linkout-0 = {http://www.cell.com//abstract/S0092-8674(09)00445-0}, day = {10}, keywords = {cpg, genome-organization, nucleosome}, month = {July}, number = {1}, pages = {114--128}, posted-at = {2009-08-05 16:16:34}, priority = {5}, title = {A Unifying Model for the Selective Regulation of Inducible Transcription by CpG Islands and Nucleosome Remodeling}, url = {http://www.cell.com//abstract/S0092-8674(09)00445-0}, volume = {138}, year = {2009} }

TY - JOUR ID - citeulike:5160460 L3 - citeulike-article-id:5160460 N2 - We describe a broad mechanistic framework for the transcriptional induction of mammalian primary response genes by Toll-like receptors and other stimuli. One major class of primary response genes is characterized by CpG-island promoters, which facilitate promiscuous induction from constitutively active chromatin without a requirement for SWI/SNF nucleosome remodeling complexes. The low nucleosome occupancy at promoters in this class can be attributed to the assembly of CpG islands into unstable nucleosomes, which may lead to SWI/SNF independence. Another major class consists of non-CpG-island promoters that assemble into stable nucleosomes, resulting in SWI/SNF dependence and a requirement for transcription factors that promote selective nucleosome remodeling. Some stimuli, including serum and tumor necrosis factor-±, exhibit a strong bias toward activation of SWI/SNF-independent CpG-island genes. In contrast, interferon-² is strongly biased toward SWI/SNF-dependent non-CpG-island genes. By activating a diverse set of transcription factors, Toll-like receptors induce both classes and others for an optimal response to microbial pathogens. IS - 1 EP - 128 TI - A Unifying Model for the Selective Regulation of Inducible Transcription by CpG Islands and Nucleosome Remodeling VL - 138 SP - 114 KW - cpg KW - genome-organization KW - nucleosome AU - Ramirez-Carrozzi, Vladimir AU - Braas, Daniel AU - Bhatt, Dev AU - Cheng, Christine AU - Hong, Christine AU - Doty, Kevin AU - Black, Joshua AU - Hoffmann, Alexander AU - Carey, Michael AU - Smale, Stephen PY - 2009/07/10/ UR - http://www.cell.com//abstract/S0092-8674(09)00445-0 ER -