Insights from genomic profiling of transcription factors. Export

@article{citeulike:5415624, abstract = {A crucial question in the field of gene regulation is whether the location at which a transcription factor binds influences its effectiveness or the mechanism by which it regulates transcription. Comprehensive transcription factor binding maps are needed to address these issues, and genome-wide mapping is now possible thanks to the technological advances of ChIP-chip and ChIP-seq. This Review discusses how recent genomic profiling of transcription factors gives insight into how binding specificity is achieved and what features of chromatin influence the ability of transcription factors to interact with the genome. It also suggests future experiments that may further our understanding of the causes and consequences of transcription factor-genome interactions.}, author = {Farnham, Peggy J.}, citeulike-article-id = {5415624}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nrg2636}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nrg2636}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19668247}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19668247}, day = {11}, doi = {10.1038/nrg2636}, issn = {1471-0064}, journal = {Nature reviews. Genetics}, keywords = {chip-seq, transcription\_factors}, month = {September}, number = {9}, pages = {605--616}, posted-at = {2009-11-08 16:24:33}, priority = {5}, publisher = {Nature Publishing Group}, title = {Insights from genomic profiling of transcription factors.}, url = {http://dx.doi.org/10.1038/nrg2636}, volume = {10}, year = {2009} }

TY - JOUR ID - citeulike:5415624 L3 - citeulike-article-id:5415624 N2 - A crucial question in the field of gene regulation is whether the location at which a transcription factor binds influences its effectiveness or the mechanism by which it regulates transcription. Comprehensive transcription factor binding maps are needed to address these issues, and genome-wide mapping is now possible thanks to the technological advances of ChIP-chip and ChIP-seq. This Review discusses how recent genomic profiling of transcription factors gives insight into how binding specificity is achieved and what features of chromatin influence the ability of transcription factors to interact with the genome. It also suggests future experiments that may further our understanding of the causes and consequences of transcription factor-genome interactions. IS - 9 JF - Nature reviews. Genetics SN - 1471-0064 EP - 616 TI - Insights from genomic profiling of transcription factors. PB - Nature Publishing Group VL - 10 SP - 605 KW - chip-seq KW - transcription_factors AU - Farnham, Peggy PY - 2009/09/11/ UR - http://dx.doi.org/10.1038/nrg2636 ER -