Genome-wide Mapping of HATs and HDACs Reveals Distinct Functions in Active and Inactive Genes Export

@article{citeulike:5666460, abstract = {Histone acetyltransferases (HATs) and deacetylases (HDACs) function antagonistically to control histone acetylation. As acetylation is a histone mark for active transcription, HATs have been associated with active and HDACs with inactive genes. We describe here genome-wide mapping of HATs and HDACs binding on chromatin and find that both are found at active genes with acetylated histones. Our data provide evidence that HATs and HDACs are both targeted to transcribed regions of active genes by phosphorylated RNA Pol II. Furthermore, the majority of HDACs in the human genome function to reset chromatin by removing acetylation at active genes. Inactive genes that are primed by MLL-mediated histone H3K4 methylation are subject to a dynamic cycle of acetylation and deacetylation by transient HAT/HDAC binding, preventing Pol II from binding to these genes but poising them for future activation. Silent genes without any H3K4 methylation signal show no evidence of being bound by HDACs.}, author = {Wang, Zhibin and Zang, Chongzhi and Cui, Kairong and Schones, Dustin E. and Barski, Artem and Peng, Weiqun and Zhao, Keji}, citeulike-article-id = {5666460}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.cell.2009.06.049}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S0092867409008411}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19698979}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19698979}, day = {04}, doi = {10.1016/j.cell.2009.06.049}, issn = {00928674}, journal = {Cell}, keywords = {analysis, chromatin\_factors, d-chromatin-organization, polymerase, wide\_mapping}, month = {September}, number = {5}, pages = {1019--1031}, posted-at = {2009-11-09 03:25:11}, priority = {2}, title = {Genome-wide Mapping of HATs and HDACs Reveals Distinct Functions in Active and Inactive Genes}, url = {http://dx.doi.org/10.1016/j.cell.2009.06.049}, volume = {138}, year = {2009} }

TY - JOUR ID - citeulike:5666460 L3 - citeulike-article-id:5666460 N2 - Histone acetyltransferases (HATs) and deacetylases (HDACs) function antagonistically to control histone acetylation. As acetylation is a histone mark for active transcription, HATs have been associated with active and HDACs with inactive genes. We describe here genome-wide mapping of HATs and HDACs binding on chromatin and find that both are found at active genes with acetylated histones. Our data provide evidence that HATs and HDACs are both targeted to transcribed regions of active genes by phosphorylated RNA Pol II. Furthermore, the majority of HDACs in the human genome function to reset chromatin by removing acetylation at active genes. Inactive genes that are primed by MLL-mediated histone H3K4 methylation are subject to a dynamic cycle of acetylation and deacetylation by transient HAT/HDAC binding, preventing Pol II from binding to these genes but poising them for future activation. Silent genes without any H3K4 methylation signal show no evidence of being bound by HDACs. IS - 5 JF - Cell SN - 00928674 EP - 1031 TI - Genome-wide Mapping of HATs and HDACs Reveals Distinct Functions in Active and Inactive Genes VL - 138 SP - 1019 KW - analysis KW - chromatin_factors KW - d-chromatin-organization KW - polymerase KW - wide_mapping AU - Wang, Zhibin AU - Zang, Chongzhi AU - Cui, Kairong AU - Schones, Dustin AU - Barski, Artem AU - Peng, Weiqun AU - Zhao, Keji PY - 2009/09/04/ UR - http://dx.doi.org/10.1016/j.cell.2009.06.049 ER -