Nanog Is the Gateway to the Pluripotent Ground State Export

@article{citeulike:5666467, abstract = {Pluripotency is generated naturally during mammalian development through formation of the epiblast, founder tissue of the embryo proper. Pluripotency can be recreated by somatic cell reprogramming. Here we present evidence that the homeodomain protein Nanog mediates acquisition of both embryonic and induced pluripotency. Production of pluripotent hybrids by cell fusion is promoted by and dependent on Nanog. In transcription factor-induced molecular reprogramming, Nanog is initially dispensable but becomes essential for dedifferentiated intermediates to transit to ground state pluripotency. In the embryo, Nanog specifically demarcates the nascent epiblast, coincident with the domain of X chromosome reprogramming. Without Nanog, pluripotency does not develop, and the inner cell mass is trapped in a pre-pluripotent, indeterminate state that is ultimately nonviable. These findings suggest that Nanog choreographs synthesis of the naive epiblast ground state in the embryo and that this function is recapitulated in the culmination of somatic cell reprogramming.}, author = {Silva, Jose and Nichols, Jennifer and Theunissen, Thorold W. and Guo, Ge and van Oosten, Anouk L. and Barrandon, Ornella and Wray, Jason and Yamanaka, Shinya and Chambers, Ian and Smith, Austin}, citeulike-article-id = {5666467}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.cell.2009.07.039}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S0092867409009696}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19703398}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19703398}, day = {21}, doi = {10.1016/j.cell.2009.07.039}, issn = {00928674}, journal = {Cell}, keywords = {differentiation-review}, month = {August}, number = {4}, pages = {722--737}, posted-at = {2009-09-11 19:19:16}, priority = {5}, title = {Nanog Is the Gateway to the Pluripotent Ground State}, url = {http://dx.doi.org/10.1016/j.cell.2009.07.039}, volume = {138}, year = {2009} }

TY - JOUR ID - citeulike:5666467 L3 - citeulike-article-id:5666467 N2 - Pluripotency is generated naturally during mammalian development through formation of the epiblast, founder tissue of the embryo proper. Pluripotency can be recreated by somatic cell reprogramming. Here we present evidence that the homeodomain protein Nanog mediates acquisition of both embryonic and induced pluripotency. Production of pluripotent hybrids by cell fusion is promoted by and dependent on Nanog. In transcription factor-induced molecular reprogramming, Nanog is initially dispensable but becomes essential for dedifferentiated intermediates to transit to ground state pluripotency. In the embryo, Nanog specifically demarcates the nascent epiblast, coincident with the domain of X chromosome reprogramming. Without Nanog, pluripotency does not develop, and the inner cell mass is trapped in a pre-pluripotent, indeterminate state that is ultimately nonviable. These findings suggest that Nanog choreographs synthesis of the naive epiblast ground state in the embryo and that this function is recapitulated in the culmination of somatic cell reprogramming. IS - 4 JF - Cell SN - 00928674 EP - 737 TI - Nanog Is the Gateway to the Pluripotent Ground State VL - 138 SP - 722 KW - differentiation-review AU - Silva, Jose AU - Nichols, Jennifer AU - Theunissen, Thorold AU - Guo, Ge AU - van Oosten, Anouk AU - Barrandon, Ornella AU - Wray, Jason AU - Yamanaka, Shinya AU - Chambers, Ian AU - Smith, Austin PY - 2009/08/21/ UR - http://dx.doi.org/10.1016/j.cell.2009.07.039 ER -