Allelic inactivation of rDNA loci Export

@article{citeulike:6057069, abstract = {10.1101/gad.544509 Human cells contain several hundred ribosomal genes (rDNA) that are clustered into nucleolar organizer regions (NORs) on the short arms of five different acrocentric chromosomes. Only \^{a}ˆ¼50\% of the gene copies are actually expressed in somatic cells. Here, we used a new cytological technique to demonstrate that rDNA is regulated allelically in a regional manner, with one parental copy of each NOR being repressed in any individual cell. This process is similar to that of X-chromosome inactivation in females. Early in development, one copy of each NOR becomes late-replicating, thus probably marking it for inactivation and subsequent targeted de novo methylation at rDNA promoter regions. Once established, this multichromosomal allelic pattern is then maintained clonally in somatic cells. This pathway may serve as an epigenetic mechanism for controlling the number of available rDNA copies during development.}, author = {Schlesinger, Sharon and Selig, Sara and Bergman, Yehudit and Cedar, Howard}, citeulike-article-id = {6057069}, citeulike-linkout-0 = {http://dx.doi.org/10.1101/gad.544509}, citeulike-linkout-1 = {http://genesdev.cshlp.org/content/23/20/2437.abstract}, citeulike-linkout-2 = {http://genesdev.cshlp.org/content/23/20/2437.full.pdf}, citeulike-linkout-3 = {http://view.ncbi.nlm.nih.gov/pubmed/19833769}, citeulike-linkout-4 = {http://www.hubmed.org/display.cgi?uids=19833769}, day = {15}, doi = {10.1101/gad.544509}, issn = {1549-5477}, journal = {Genes \& Development}, keywords = {allelic-specific, replication}, month = {October}, number = {20}, pages = {2437--2447}, posted-at = {2009-11-08 00:38:53}, priority = {2}, title = {Allelic inactivation of rDNA loci}, url = {http://dx.doi.org/10.1101/gad.544509}, volume = {23}, year = {2009} }

TY - JOUR ID - citeulike:6057069 L3 - citeulike-article-id:6057069 N2 - 10.1101/gad.544509 Human cells contain several hundred ribosomal genes (rDNA) that are clustered into nucleolar organizer regions (NORs) on the short arms of five different acrocentric chromosomes. Only ∼50% of the gene copies are actually expressed in somatic cells. Here, we used a new cytological technique to demonstrate that rDNA is regulated allelically in a regional manner, with one parental copy of each NOR being repressed in any individual cell. This process is similar to that of X-chromosome inactivation in females. Early in development, one copy of each NOR becomes late-replicating, thus probably marking it for inactivation and subsequent targeted de novo methylation at rDNA promoter regions. Once established, this multichromosomal allelic pattern is then maintained clonally in somatic cells. This pathway may serve as an epigenetic mechanism for controlling the number of available rDNA copies during development. IS - 20 JF - Genes & Development SN - 1549-5477 EP - 2447 TI - Allelic inactivation of rDNA loci VL - 23 SP - 2437 KW - allelic-specific KW - replication AU - Schlesinger, Sharon AU - Selig, Sara AU - Bergman, Yehudit AU - Cedar, Howard PY - 2009/10/15/ UR - http://dx.doi.org/10.1101/gad.544509 ER -