Dynamic positioning of the fission yeast cell division plane. Export

@article{citeulike:2646052, abstract = {A key question in cytokinesis is how the cell division plane is positioned. Whereas microtubules of the mitotic apparatus specify the division site in animal cells, we show here that the nucleus plays this role in the fission yeast Schizosaccharomyces pombe. By centrifuging cells to move the nucleus, we find that the nucleus (or a nuclear-associated structure) actively influences the position of contractile ring assembly during early mitosis. Displacement of the nucleus during this induction period can lead to formation of multiple rings. The nucleus signals its position in a microtubule-independent manner by emitting the protein mid1p. Furthermore, movement of ring fragments together minimizes formation of multiple division sites. These dynamic mechanisms of ring positioning provide a robust coordination of nuclear and cell division.}, address = {Department of Microbiology, Columbia University College of Physicians and Surgeons, 701 West 168th Street, New York, NY 10032, USA.}, author = {Daga, R. R. and Chang, F.}, citeulike-article-id = {2646052}, citeulike-linkout-0 = {http://dx.doi.org/10.1073/pnas.0409021102}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/15928091}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=15928091}, day = {7}, doi = {10.1073/pnas.0409021102}, issn = {0027-8424}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, keywords = {centrifugation}, month = {June}, number = {23}, pages = {8228--8232}, posted-at = {2008-04-09 16:00:19}, priority = {2}, title = {Dynamic positioning of the fission yeast cell division plane.}, url = {http://dx.doi.org/10.1073/pnas.0409021102}, volume = {102}, year = {2005} }

TY - JOUR ID - citeulike:2646052 L3 - citeulike-article-id:2646052 N2 - A key question in cytokinesis is how the cell division plane is positioned. Whereas microtubules of the mitotic apparatus specify the division site in animal cells, we show here that the nucleus plays this role in the fission yeast Schizosaccharomyces pombe. By centrifuging cells to move the nucleus, we find that the nucleus (or a nuclear-associated structure) actively influences the position of contractile ring assembly during early mitosis. Displacement of the nucleus during this induction period can lead to formation of multiple rings. The nucleus signals its position in a microtubule-independent manner by emitting the protein mid1p. Furthermore, movement of ring fragments together minimizes formation of multiple division sites. These dynamic mechanisms of ring positioning provide a robust coordination of nuclear and cell division. IS - 23 JF - Proceedings of the National Academy of Sciences of the United States of America SN - 0027-8424 AD - Department of Microbiology, Columbia University College of Physicians and Surgeons, 701 West 168th Street, New York, NY 10032, USA. EP - 8232 TI - Dynamic positioning of the fission yeast cell division plane. VL - 102 SP - 8228 KW - centrifugation AU - Daga, RR AU - Chang, F PY - 2005/06/07/ UR - http://dx.doi.org/10.1073/pnas.0409021102 ER -