Anatomy and physiology of the basal ganglia: implications for deep brain stimulation for Parkinson's disease. Export

@article{citeulike:2882322, abstract = {Central to surgical management of movement disorders is an understanding of the anatomy and physiology of the basal ganglia. The basal ganglia have been a target for neuromodulation surgery since Russell Meyers' pioneering works in the late 1930s. With the development of deep brain stimulation as the gold standard of surgical intervention for movement disorders, there has been a concomitant evolution in the understanding of the role the basal ganglia plays in the genesis of normal and abnormal motor behaviors. The fundamental concept of the cortico-striato-pallido-thalamocortical loop will be explored in the context of deep brain stimulation. The current targets for deep brain stimulation for Parkinson's disease, the subthalamic nucleus, the globus pallidus internus, and the ventral intermediate nucleus, will be discussed in the framework of the current physiological and anatomical models of Parkinson's disease (PD). Finally, the current understandings of the mechanisms underpinning the beneficial effects of deep brain stimulation for PD will be discussed.}, address = {Department of Neurosurgery, Medical College of Wisconsin, and Clement J. Zablocki VA Medical Center, Milwaukee, Wisconsin 53202, USA. bkopell@neuroscience.mcw.edu}, author = {Kopell, B. H. and Rezai, A. R. and Chang, J. W. and Vitek, J. L.}, citeulike-article-id = {2882322}, citeulike-linkout-0 = {http://dx.doi.org/10.1002/mds.20958}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/16810674}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=16810674}, doi = {10.1002/mds.20958}, issn = {0885-3185}, journal = {Movement disorders : official journal of the Movement Disorder Society}, keywords = {basal, ganglia}, month = {June}, posted-at = {2008-06-11 10:10:08}, priority = {2}, title = {Anatomy and physiology of the basal ganglia: implications for deep brain stimulation for Parkinson's disease.}, url = {http://dx.doi.org/10.1002/mds.20958}, volume = {21 Suppl 14}, year = {2006} }

TY - JOUR ID - citeulike:2882322 L3 - citeulike-article-id:2882322 N2 - Central to surgical management of movement disorders is an understanding of the anatomy and physiology of the basal ganglia. The basal ganglia have been a target for neuromodulation surgery since Russell Meyers' pioneering works in the late 1930s. With the development of deep brain stimulation as the gold standard of surgical intervention for movement disorders, there has been a concomitant evolution in the understanding of the role the basal ganglia plays in the genesis of normal and abnormal motor behaviors. The fundamental concept of the cortico-striato-pallido-thalamocortical loop will be explored in the context of deep brain stimulation. The current targets for deep brain stimulation for Parkinson's disease, the subthalamic nucleus, the globus pallidus internus, and the ventral intermediate nucleus, will be discussed in the framework of the current physiological and anatomical models of Parkinson's disease (PD). Finally, the current understandings of the mechanisms underpinning the beneficial effects of deep brain stimulation for PD will be discussed. JF - Movement disorders : official journal of the Movement Disorder Society SN - 0885-3185 AD - Department of Neurosurgery, Medical College of Wisconsin, and Clement J. Zablocki VA Medical Center, Milwaukee, Wisconsin 53202, USA. bkopell@neuroscience.mcw.edu TI - Anatomy and physiology of the basal ganglia: implications for deep brain stimulation for Parkinson's disease. VL - 21 Suppl 14 KW - basal KW - ganglia AU - Kopell, BH AU - Rezai, AR AU - Chang, JW AU - Vitek, JL PY - 2006/06// UR - http://dx.doi.org/10.1002/mds.20958 ER -