Axon guidance and synaptic maintenance: preclinical markers for neurodegenerative disease and therapeutics. Export

@article{citeulike:4184034, abstract = {Axon-guidance-pathway molecules are involved in connectivity and repair throughout life (beyond guiding brain wiring during fetal development). One study found that variations (single-nucleotide polymorphisms [SNPs]) in axon-guidance-pathway genes were predictive of three Parkinson's disease (PD) outcomes (susceptibility, survival free of PD and age at onset of PD) in genome-wide association (GWA) datasets. The axon-guidance-pathway genes DCC, EPHB1, NTNG1, SEMA5A and SLIT3 were represented by SNPs predicting PD outcomes. Beyond GWA analyses, we also present relevant neurobiological roles of these axon-guidance-pathway molecules and consider mechanisms by which abnormal axon-guidance-molecule signaling can cause loss of connectivity and, ultimately, PD. Novel drugs and treatments could emerge from this new understanding.}, author = {Lin, Ling and Lesnick, Timothy G. and Maraganore, Demetrius M. and Isacson, Ole}, citeulike-article-id = {4184034}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.tins.2008.11.006}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S0166223609000022}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19162339}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19162339}, doi = {10.1016/j.tins.2008.11.006}, issn = {0166-2236}, journal = {Trends in neurosciences}, keywords = {axona, degeneration, guidance}, month = {March}, number = {3}, pages = {142--149}, posted-at = {2009-03-27 05:48:22}, priority = {2}, title = {Axon guidance and synaptic maintenance: preclinical markers for neurodegenerative disease and therapeutics.}, url = {http://dx.doi.org/10.1016/j.tins.2008.11.006}, volume = {32}, year = {2009} }

TY - JOUR ID - citeulike:4184034 L3 - citeulike-article-id:4184034 N2 - Axon-guidance-pathway molecules are involved in connectivity and repair throughout life (beyond guiding brain wiring during fetal development). One study found that variations (single-nucleotide polymorphisms [SNPs]) in axon-guidance-pathway genes were predictive of three Parkinson's disease (PD) outcomes (susceptibility, survival free of PD and age at onset of PD) in genome-wide association (GWA) datasets. The axon-guidance-pathway genes DCC, EPHB1, NTNG1, SEMA5A and SLIT3 were represented by SNPs predicting PD outcomes. Beyond GWA analyses, we also present relevant neurobiological roles of these axon-guidance-pathway molecules and consider mechanisms by which abnormal axon-guidance-molecule signaling can cause loss of connectivity and, ultimately, PD. Novel drugs and treatments could emerge from this new understanding. IS - 3 JF - Trends in neurosciences SN - 0166-2236 EP - 149 TI - Axon guidance and synaptic maintenance: preclinical markers for neurodegenerative disease and therapeutics. VL - 32 SP - 142 KW - axona KW - degeneration KW - guidance AU - Lin, Ling AU - Lesnick, Timothy AU - Maraganore, Demetrius AU - Isacson, Ole PY - 2009/03// UR - http://dx.doi.org/10.1016/j.tins.2008.11.006 ER -