Diffusion tensor metrics, <I>T</I><SUB><FONT SIZE='-1'>2</FONT></SUB> relaxation, and volumetry of the naturally aging human caudate nuclei in healthy young and middle-aged adults: Possible implications for the neurobiology of human brain aging and disease Export

@article{citeulike:4619156, abstract = {In this study of a cohort of 33 young and middle-age adults (19-59 years) we report simultaneous measurements of normal age-related changes in the caudate nuclei volume, diffusion tensor metrics, and T2 relaxation time. Both the absolute caudate volume and its ratio relative to the total intracranial volume decreased rapidly with age in both men and women (r = -0.55; P \&lt; 0.001). The fractional diffusion tensor anisotropy of the caudate nuclei increased with age in both males and females (r = 0.48; P = 0.005). The corresponding age correlations of the caudate axial (r = 0.17; P = 0.35), transverse (r = -0.12; P = 0.50), mean diffusivities (r = 0.018; P = 0.92), and T2 relaxation times (r = 0.194; P = 0.28) were weaker and did not reach statistical significance (P \&gt; 0.05). Our preliminary findings warrant further studies on the older and aging adults and indicate that caudate diffusion tensor imaging-derived metrics can be used as surrogates in modeling the neuronal substrates of gray matter atrophy. Magn Reson Med, 2007. {\copyright} 2007 Wiley-Liss, Inc.}, address = {Department of Diagnostic and Interventional Imaging, University of Texas Health Science Center at Houston, Houston Texas; Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, Nebraska; Department of Radiology, University of Nebraska Medical Center, Omaha, Nebraska}, author = {Hasan, Khader M. and Halphen, Christopher and Boska, Michael D. and Narayana, Ponnada A.}, citeulike-article-id = {4619156}, citeulike-linkout-0 = {http://dx.doi.org/10.1002/mrm.21434}, citeulike-linkout-1 = {http://www3.interscience.wiley.com/cgi-bin/abstract/117351482/ABSTRACT}, doi = {10.1002/mrm.21434}, journal = {Magnetic Resonance in Medicine}, keywords = {ageing, dti}, number = {1}, pages = {7--13}, posted-at = {2009-05-24 11:29:23}, priority = {2}, title = {Diffusion tensor metrics, <I>T</I><SUB><FONT SIZE='-1'>2</FONT></SUB> relaxation, and volumetry of the naturally aging human caudate nuclei in healthy young and middle-aged adults: Possible implications for the neurobiology of human brain aging and disease}, url = {http://dx.doi.org/10.1002/mrm.21434}, volume = {59}, year = {2008} }

TY - JOUR ID - citeulike:4619156 L3 - citeulike-article-id:4619156 N2 - In this study of a cohort of 33 young and middle-age adults (19-59 years) we report simultaneous measurements of normal age-related changes in the caudate nuclei volume, diffusion tensor metrics, and T2 relaxation time. Both the absolute caudate volume and its ratio relative to the total intracranial volume decreased rapidly with age in both men and women (r = -0.55; P &lt; 0.001). The fractional diffusion tensor anisotropy of the caudate nuclei increased with age in both males and females (r = 0.48; P = 0.005). The corresponding age correlations of the caudate axial (r = 0.17; P = 0.35), transverse (r = -0.12; P = 0.50), mean diffusivities (r = 0.018; P = 0.92), and T2 relaxation times (r = 0.194; P = 0.28) were weaker and did not reach statistical significance (P &gt; 0.05). Our preliminary findings warrant further studies on the older and aging adults and indicate that caudate diffusion tensor imaging-derived metrics can be used as surrogates in modeling the neuronal substrates of gray matter atrophy. Magn Reson Med, 2007. © 2007 Wiley-Liss, Inc. IS - 1 JF - Magnetic Resonance in Medicine AD - Department of Diagnostic and Interventional Imaging, University of Texas Health Science Center at Houston, Houston Texas; Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, Nebraska; Department of Radiology, University of Nebraska Medical Center, Omaha, Nebraska EP - 13 TI - Diffusion tensor metrics, <I>T</I><SUB><FONT SIZE='-1'>2</FONT></SUB> relaxation, and volumetry of the naturally aging human caudate nuclei in healthy young and middle-aged adults: Possible implications for the neurobiology of human brain aging and disease VL - 59 SP - 7 KW - ageing KW - dti AU - Hasan, Khader AU - Halphen, Christopher AU - Boska, Michael AU - Narayana, Ponnada PY - 2008/// UR - http://dx.doi.org/10.1002/mrm.21434 ER -