Changes of functional connectivity of the motor network in the resting state in Parkinson's disease Export

@article{citeulike:4779565, abstract = {We used functional MRI (fMRI) and a network model based on graph theory to measure functional connectivity of brain motor network in the resting state in patients with Parkinson's disease (PD). FMRIs were acquired in 22 PD patients before and after levodopa administration, and in age- and sex-matched normal controls. The total connectivity degree of each region within the motor network was calculated and compared between patients and controls. We found that PD patients at off state had significantly decreased functional connectivity in the supplementary motor area, left dorsal lateral prefrontal cortex and left putamen, and had increased functional connectivity in the left cerebellum, left primary motor cortex, and left parietal cortex compared to normal subjects. Administration of levodopa relatively normalized the pattern of functional connectivity in PD patients. The functional connectivity in most of regions in the motor network correlated with the Unified Parkinson's Disease Rating Scale motor score in the patients. Our findings demonstrate that the pattern of functional connectivity of the motor network in the resting state is disrupted in PD. This change is secondary to dopamine deficiency, and related to the severity of the disease. We postulate that this abnormal functional connectivity of motor network in the baseline state is possibly an important factor contributing to some motor deficits in PD, e.g. akinesia.}, author = {Wu, Tao and Wang, Liang and Chen, Yi and Zhao, Cheng and Li, Kuncheng and Chan, Piu}, citeulike-article-id = {4779565}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.neulet.2009.05.046}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S0304394009006703}, day = {21}, doi = {10.1016/j.neulet.2009.05.046}, issn = {03043940}, journal = {Neuroscience Letters}, keywords = {connectivity, parkinsonism, resting}, month = {August}, number = {1}, pages = {6--10}, posted-at = {2009-09-22 07:35:17}, priority = {2}, title = {Changes of functional connectivity of the motor network in the resting state in Parkinson's disease}, url = {http://dx.doi.org/10.1016/j.neulet.2009.05.046}, volume = {460}, year = {2009} }

TY - JOUR ID - citeulike:4779565 L3 - citeulike-article-id:4779565 N2 - We used functional MRI (fMRI) and a network model based on graph theory to measure functional connectivity of brain motor network in the resting state in patients with Parkinson's disease (PD). FMRIs were acquired in 22 PD patients before and after levodopa administration, and in age- and sex-matched normal controls. The total connectivity degree of each region within the motor network was calculated and compared between patients and controls. We found that PD patients at off state had significantly decreased functional connectivity in the supplementary motor area, left dorsal lateral prefrontal cortex and left putamen, and had increased functional connectivity in the left cerebellum, left primary motor cortex, and left parietal cortex compared to normal subjects. Administration of levodopa relatively normalized the pattern of functional connectivity in PD patients. The functional connectivity in most of regions in the motor network correlated with the Unified Parkinson's Disease Rating Scale motor score in the patients. Our findings demonstrate that the pattern of functional connectivity of the motor network in the resting state is disrupted in PD. This change is secondary to dopamine deficiency, and related to the severity of the disease. We postulate that this abnormal functional connectivity of motor network in the baseline state is possibly an important factor contributing to some motor deficits in PD, e.g. akinesia. IS - 1 JF - Neuroscience Letters SN - 03043940 EP - 10 TI - Changes of functional connectivity of the motor network in the resting state in Parkinson's disease VL - 460 SP - 6 KW - connectivity KW - parkinsonism KW - resting AU - Wu, Tao AU - Wang, Liang AU - Chen, Yi AU - Zhao, Cheng AU - Li, Kuncheng AU - Chan, Piu PY - 2009/08/21/ UR - http://dx.doi.org/10.1016/j.neulet.2009.05.046 ER -