Neuropathology of progressive supranuclear palsy Export

@article{citeulike:5908907, abstract = {The fundamental neuropathological findings of progressive supranuclear palsy (PSP) are presented, based on 14 autopsied cases of PSP. The blunt pathologies of PSP are degeneration in the substantia nigra, globus pallidus, subthalamic nuclei, dentate nucleus of the cerebellum and red nucleus, where there are neuronal loss, gliosis and neurofibrillary changes, to varying degree. In addition, the atrophy of the midbrain, especially the characteristic pattern of tegmental atrophy of the pons exhibiting a hand-bag profile, is an important finding. Hypertrophy of inferior olivary nucleus is frequently observed, suggesting the existence of lesions in the dentato-olivary system. Hypoxemic affects at the agonal stage should be noted because death of Purkinje cells of the cerebellum leads to degeneration of their axons and subsequently to the decrease of grumose degeneration in the dentate nucleus. Familial PSP have been reported by several authors but all case in the present study were sporadic.}, address = {Division of Pathology, Kanagawa Rehabilitation Center; Department of Neuropsychiatry, Faculty of Medicine, University of Tokyo; Department of Neurology, School of Medicine, Yokohama City University; Department of Psychiatry, Yokohama Comprehensive Care Continuum, Japan}, author = {Inoue, Masayuki and Yagishita, Saburo and Amano, Naoji and Takahashi, Tatsuya and Hanihara, Tokiji}, citeulike-article-id = {5908907}, citeulike-linkout-0 = {http://dx.doi.org/10.1111/j.1440-1789.1996.tb00191.x}, citeulike-linkout-1 = {http://www3.interscience.wiley.com/cgi-bin/abstract/119219093/ABSTRACT}, doi = {10.1111/j.1440-1789.1996.tb00191.x}, issn = {1440-1789}, journal = {Neuropathology}, keywords = {psp}, number = {4}, pages = {257--261}, posted-at = {2009-10-08 10:11:46}, priority = {2}, title = {Neuropathology of progressive supranuclear palsy}, url = {http://dx.doi.org/10.1111/j.1440-1789.1996.tb00191.x}, volume = {16}, year = {1996} }

TY - JOUR ID - citeulike:5908907 L3 - citeulike-article-id:5908907 N2 - The fundamental neuropathological findings of progressive supranuclear palsy (PSP) are presented, based on 14 autopsied cases of PSP. The blunt pathologies of PSP are degeneration in the substantia nigra, globus pallidus, subthalamic nuclei, dentate nucleus of the cerebellum and red nucleus, where there are neuronal loss, gliosis and neurofibrillary changes, to varying degree. In addition, the atrophy of the midbrain, especially the characteristic pattern of tegmental atrophy of the pons exhibiting a hand-bag profile, is an important finding. Hypertrophy of inferior olivary nucleus is frequently observed, suggesting the existence of lesions in the dentato-olivary system. Hypoxemic affects at the agonal stage should be noted because death of Purkinje cells of the cerebellum leads to degeneration of their axons and subsequently to the decrease of grumose degeneration in the dentate nucleus. Familial PSP have been reported by several authors but all case in the present study were sporadic. IS - 4 JF - Neuropathology SN - 1440-1789 AD - Division of Pathology, Kanagawa Rehabilitation Center; Department of Neuropsychiatry, Faculty of Medicine, University of Tokyo; Department of Neurology, School of Medicine, Yokohama City University; Department of Psychiatry, Yokohama Comprehensive Care Continuum, Japan EP - 261 TI - Neuropathology of progressive supranuclear palsy VL - 16 SP - 257 KW - psp AU - Inoue, Masayuki AU - Yagishita, Saburo AU - Amano, Naoji AU - Takahashi, Tatsuya AU - Hanihara, Tokiji PY - 1996/// UR - http://dx.doi.org/10.1111/j.1440-1789.1996.tb00191.x ER -