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Re-creation of the genetic composition of a founder population Export

by: William Klitz, Martin Maiers, Loren Gragert
Human Genetics, Vol. 124, No. 4. (1 November 2008), pp. 417-421.

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demografia genetica

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Abstract  Human ethnic groups are frequently comprised of two or more founder populations. One of these founding populations is often available for contemporary sampling. We describe a method for reconstructing the composition of a missing founder population using the highly informative haplotypes comprising the HLA system. An application of the method is demonstrated using bone marrow registry samples of African Americans. We use contemporary samples of African Americans and European Americans to derive haplotypes of the West African founder populations. This approach may also be useful for reconstructing ancestral haplotypes for regions elsewhere in the genome.


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