A Probabilistic Functional Network of Yeast Genes Export

@article{citeulike:134628, abstract = {A conceptual framework for integrating diverse functional genomics data was developed by reinterpreting experiments to provide numerical likelihoods that genes are functionally linked. This allows direct comparison and integration of different classes of data. The resulting probabilistic gene network estimates the functional coupling between genes. Within this framework, we reconstructed an extensive, high-quality functional gene network for Saccharomyces cerevisiae, consisting of 4681 ([\~{}]81\%) of the known yeast genes linked by [\~{}]34,000 probabilistic linkages comparable in accuracy to small-scale interaction assays. The integrated linkages distinguish true from false-positive interactions in earlier data sets; new interactions emerge from genes' network contexts, as shown for genes in chromatin modification and ribosome biogenesis. 10.1126/science.1099511}, address = {Center for Systems and Synthetic Biology, Institute for Molecular Biology, University of Texas at Austin, Austin, TX 78712-1064, USA.}, author = {Lee, Insuk and Date, Shailesh V. and Adai, Alex T. and Marcotte, Edward M.}, citeulike-article-id = {134628}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1099511}, citeulike-linkout-1 = {http://www.sciencemag.org/cgi/content/abstract/306/5701/1555}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/15567862}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=15567862}, day = {26}, doi = {10.1126/science.1099511}, issn = {1095-9203}, journal = {Science}, keywords = {animal-model, applied-math, bio, bio-stat, bioinformatics, biology, class, clustering, computational, function, functional-genome, gene-expression, gene-gene, integrative, interactions, interactome, memo, methods, network, networks, nw\_modularity, pathway\_prediction, ppi, predict\_function, predictions, probmod, protein-protein, roberto, yeast}, month = {November}, number = {5701}, pages = {1555--1558}, posted-at = {2009-09-12 00:46:26}, priority = {2}, title = {A Probabilistic Functional Network of Yeast Genes}, url = {http://dx.doi.org/10.1126/science.1099511}, volume = {306}, year = {2004} }

TY - JOUR ID - citeulike:134628 L3 - citeulike-article-id:134628 N2 - A conceptual framework for integrating diverse functional genomics data was developed by reinterpreting experiments to provide numerical likelihoods that genes are functionally linked. This allows direct comparison and integration of different classes of data. The resulting probabilistic gene network estimates the functional coupling between genes. Within this framework, we reconstructed an extensive, high-quality functional gene network for Saccharomyces cerevisiae, consisting of 4681 ([~]81%) of the known yeast genes linked by [~]34,000 probabilistic linkages comparable in accuracy to small-scale interaction assays. The integrated linkages distinguish true from false-positive interactions in earlier data sets; new interactions emerge from genes' network contexts, as shown for genes in chromatin modification and ribosome biogenesis. 10.1126/science.1099511 IS - 5701 JF - Science SN - 1095-9203 AD - Center for Systems and Synthetic Biology, Institute for Molecular Biology, University of Texas at Austin, Austin, TX 78712-1064, USA. EP - 1558 TI - A Probabilistic Functional Network of Yeast Genes VL - 306 SP - 1555 KW - animal-model KW - applied-math KW - bio KW - bio-stat KW - bioinformatics KW - biology KW - class KW - clustering KW - computational KW - function KW - functional-genome KW - gene-expression KW - gene-gene KW - integrative KW - interactions KW - interactome KW - memo KW - methods KW - network KW - networks KW - nw_modularity KW - pathway_prediction KW - ppi KW - predict_function KW - predictions KW - probmod KW - protein-protein KW - roberto KW - yeast AU - Lee, Insuk AU - Date, Shailesh AU - Adai, Alex AU - Marcotte, Edward PY - 2004/11/26/ UR - http://dx.doi.org/10.1126/science.1099511 ER -