A simple model of cortical dynamics explains variability and state dependence of sensory responses in urethane-anesthetized auditory cortex. Export

@article{citeulike:5651178, abstract = {The responses of neocortical cells to sensory stimuli are variable and state dependent. It has been hypothesized that intrinsic cortical dynamics play an important role in trial-to-trial variability; the precise nature of this dependence, however, is poorly understood. We show here that in auditory cortex of urethane-anesthetized rats, population responses to click stimuli can be quantitatively predicted on a trial-by-trial basis by a simple dynamical system model estimated from spontaneous activity immediately preceding stimulus presentation. Changes in cortical state correspond consistently to changes in model dynamics, reflecting a nonlinear, self-exciting system in synchronized states and an approximately linear system in desynchronized states. We propose that the complex and state-dependent pattern of trial-to-trial variability can be explained by a simple principle: sensory responses are shaped by the same intrinsic dynamics that govern ongoing spontaneous activity.}, author = {Curto, Carina and Sakata, Shuzo and Marguet, Stephan and Itskov, Vladimir and Harris, Kenneth D.}, citeulike-article-id = {5651178}, citeulike-linkout-0 = {http://dx.doi.org/10.1523/JNEUROSCI.2053-09.2009}, citeulike-linkout-1 = {http://www.jneurosci.org/cgi/content/abstract/29/34/10600}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19710313}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19710313}, day = {26}, doi = {10.1523/JNEUROSCI.2053-09.2009}, issn = {1529-2401}, journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience}, keywords = {audito, sponta}, month = {August}, number = {34}, pages = {10600--10612}, posted-at = {2009-09-10 18:22:31}, priority = {2}, title = {A simple model of cortical dynamics explains variability and state dependence of sensory responses in urethane-anesthetized auditory cortex.}, url = {http://dx.doi.org/10.1523/JNEUROSCI.2053-09.2009}, volume = {29}, year = {2009} }

TY - JOUR ID - citeulike:5651178 L3 - citeulike-article-id:5651178 N2 - The responses of neocortical cells to sensory stimuli are variable and state dependent. It has been hypothesized that intrinsic cortical dynamics play an important role in trial-to-trial variability; the precise nature of this dependence, however, is poorly understood. We show here that in auditory cortex of urethane-anesthetized rats, population responses to click stimuli can be quantitatively predicted on a trial-by-trial basis by a simple dynamical system model estimated from spontaneous activity immediately preceding stimulus presentation. Changes in cortical state correspond consistently to changes in model dynamics, reflecting a nonlinear, self-exciting system in synchronized states and an approximately linear system in desynchronized states. We propose that the complex and state-dependent pattern of trial-to-trial variability can be explained by a simple principle: sensory responses are shaped by the same intrinsic dynamics that govern ongoing spontaneous activity. IS - 34 JF - The Journal of neuroscience : the official journal of the Society for Neuroscience SN - 1529-2401 EP - 10612 TI - A simple model of cortical dynamics explains variability and state dependence of sensory responses in urethane-anesthetized auditory cortex. VL - 29 SP - 10600 KW - audito KW - sponta AU - Curto, Carina AU - Sakata, Shuzo AU - Marguet, Stephan AU - Itskov, Vladimir AU - Harris, Kenneth PY - 2009/08/26/ UR - http://dx.doi.org/10.1523/JNEUROSCI.2053-09.2009 ER -