Homozygous deletions and chromosome amplifications in human lung carcinomas revealed by single nucleotide polymorphism array analysis. Export

@article{citeulike:882381, abstract = {Genome-wide copy number changes were analyzed in 70 primary human lung carcinoma specimens and 31 cell lines derived from human lung carcinomas, with high-density arrays representing approximately 115,000 single nucleotide polymorphism loci. In addition to previously characterized loci, two regions of homozygous deletion were found, one near the PTPRD locus on chromosome segment 9p23 in four samples representing both small cell lung carcinoma (SCLC) and non-small cell lung carcinoma (NSCLC) and the second on chromosome segment 3q25 in one sample each of NSCLC and SCLC. High-level amplifications were identified within chromosome segment 8q12-13 in two SCLC specimens, 12p11 in two NSCLC specimens and 22q11 in four NSCLC specimens. Systematic copy number analysis of tyrosine kinase genes identified high-level amplification of EGFR in three NSCLC specimens, FGFR1 in two specimens and ERBB2 and MET in one specimen each. EGFR amplification was shown to be independent of kinase domain mutational status.}, address = {Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA.}, author = {Zhao, X. and Weir, B. A. and LaFramboise, T. and Lin, M. and Beroukhim, R. and Garraway, L. and Beheshti, J. and Lee, J. C. and Naoki, K. and Richards, W. G. and Sugarbaker, D. and Chen, F. and Rubin, M. A. and J\"{a}nne, P. A. and Girard, L. and Minna, J. and Christiani, D. and Li, C. and Sellers, W. R. and Meyerson, M.}, citeulike-article-id = {882381}, citeulike-linkout-0 = {http://dx.doi.org/10.1158/0008-5472.CAN-04-4603}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/15994928}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=15994928}, day = {1}, doi = {10.1158/0008-5472.CAN-04-4603}, issn = {0008-5472}, journal = {Cancer Res}, keywords = {amplification, egfr, mutation}, month = {July}, number = {13}, pages = {5561--5570}, posted-at = {2006-10-03 07:17:47}, priority = {2}, title = {Homozygous deletions and chromosome amplifications in human lung carcinomas revealed by single nucleotide polymorphism array analysis.}, url = {http://dx.doi.org/10.1158/0008-5472.CAN-04-4603}, volume = {65}, year = {2005} }

TY - JOUR ID - citeulike:882381 L3 - citeulike-article-id:882381 N2 - Genome-wide copy number changes were analyzed in 70 primary human lung carcinoma specimens and 31 cell lines derived from human lung carcinomas, with high-density arrays representing approximately 115,000 single nucleotide polymorphism loci. In addition to previously characterized loci, two regions of homozygous deletion were found, one near the PTPRD locus on chromosome segment 9p23 in four samples representing both small cell lung carcinoma (SCLC) and non-small cell lung carcinoma (NSCLC) and the second on chromosome segment 3q25 in one sample each of NSCLC and SCLC. High-level amplifications were identified within chromosome segment 8q12-13 in two SCLC specimens, 12p11 in two NSCLC specimens and 22q11 in four NSCLC specimens. Systematic copy number analysis of tyrosine kinase genes identified high-level amplification of EGFR in three NSCLC specimens, FGFR1 in two specimens and ERBB2 and MET in one specimen each. EGFR amplification was shown to be independent of kinase domain mutational status. IS - 13 JF - Cancer Res SN - 0008-5472 AD - Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA. EP - 5570 TI - Homozygous deletions and chromosome amplifications in human lung carcinomas revealed by single nucleotide polymorphism array analysis. VL - 65 SP - 5561 KW - amplification KW - egfr KW - mutation AU - Zhao, X AU - Weir, BA AU - LaFramboise, T AU - Lin, M AU - Beroukhim, R AU - Garraway, L AU - Beheshti, J AU - Lee, JC AU - Naoki, K AU - Richards, WG AU - Sugarbaker, D AU - Chen, F AU - Rubin, MA AU - Jänne, PA AU - Girard, L AU - Minna, J AU - Christiani, D AU - Li, C AU - Sellers, WR AU - Meyerson, M PY - 2005/07/01/ UR - http://dx.doi.org/10.1158/0008-5472.CAN-04-4603 ER -