IKKbeta programs to turn on the GADD45alpha-MKK4-JNK apoptotic cascade specifically via p50 NF-kappaB in arsenite response Export

@article{citeulike:983927, abstract = {Cross talk between NF-{kappa}B and c-Jun N-terminal kinases (JNKs) has been implicated in the cell life and death decision under various stresses. Functional suppression of JNK activation by NF-{kappa}B has recently been proposed as a key cellular survival mechanism and contributes to cancer cells escaping from apoptosis. We provide a novel scenario of the proapoptotic role of I{kappa}B kinase {beta} (IKK{beta})-NF-{kappa}B, which can act as the activator of the JNK pathway through the induction of GADD45{alpha} for triggering MKK4/JNK activation, in response to the stimulation of arsenite, a cancer therapeutic reagent. This effect of IKK{beta}-NF-{kappa}B is dependent on p50 but not the p65/relA NF-{kappa}B subunit, which can increase the stability of GADD45{alpha} protein through suppressing its ubiquitination and proteasome-dependent degradation. IKK{beta}-NF-{kappa}B can therefore either activate or suppress the JNK cascade and consequently mediate pro- or antiapoptotic effects, depending on the manner of its induction. Furthermore, the NF-{kappa}B p50 subunit can exert a novel regulatory function on protein modification independent of the classical NF-{kappa}B transcriptional activity. 10.1083/jcb.200602149}, author = {Song, Lun and Li, Jingxia and Zhang, Dongyun and Liu, Zheng-Gang and Ye, Jianping and Zhan, Qimin and Shen, Han-Ming and Whiteman, Matt and Huang, Chuanshu}, citeulike-article-id = {983927}, citeulike-linkout-0 = {http://dx.doi.org/10.1083/jcb.200602149}, citeulike-linkout-1 = {http://www.jcb.org/cgi/content/abstract/175/4/607}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/17116751}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=17116751}, day = {20}, doi = {10.1083/jcb.200602149}, journal = {J. Cell Biol.}, keywords = {arsenite, gadd45, jnk, nfkb}, month = {November}, number = {4}, pages = {607--617}, posted-at = {2006-12-08 02:06:01}, priority = {2}, title = {IKK{beta} programs to turn on the GADD45{alpha}-MKK4-JNK apoptotic cascade specifically via p50 NF-{kappa}B in arsenite response}, url = {http://dx.doi.org/10.1083/jcb.200602149}, volume = {175}, year = {2006} }

TY - JOUR ID - citeulike:983927 L3 - citeulike-article-id:983927 N2 - Cross talk between NF-{kappa}B and c-Jun N-terminal kinases (JNKs) has been implicated in the cell life and death decision under various stresses. Functional suppression of JNK activation by NF-{kappa}B has recently been proposed as a key cellular survival mechanism and contributes to cancer cells escaping from apoptosis. We provide a novel scenario of the proapoptotic role of I{kappa}B kinase {beta} (IKK{beta})-NF-{kappa}B, which can act as the activator of the JNK pathway through the induction of GADD45{alpha} for triggering MKK4/JNK activation, in response to the stimulation of arsenite, a cancer therapeutic reagent. This effect of IKK{beta}-NF-{kappa}B is dependent on p50 but not the p65/relA NF-{kappa}B subunit, which can increase the stability of GADD45{alpha} protein through suppressing its ubiquitination and proteasome-dependent degradation. IKK{beta}-NF-{kappa}B can therefore either activate or suppress the JNK cascade and consequently mediate pro- or antiapoptotic effects, depending on the manner of its induction. Furthermore, the NF-{kappa}B p50 subunit can exert a novel regulatory function on protein modification independent of the classical NF-{kappa}B transcriptional activity. 10.1083/jcb.200602149 IS - 4 JF - J. Cell Biol. EP - 617 TI - IKK{beta} programs to turn on the GADD45{alpha}-MKK4-JNK apoptotic cascade specifically via p50 NF-{kappa}B in arsenite response VL - 175 SP - 607 KW - arsenite KW - gadd45 KW - jnk KW - nfkb AU - Song, Lun AU - Li, Jingxia AU - Zhang, Dongyun AU - Liu, Zheng-Gang AU - Ye, Jianping AU - Zhan, Qimin AU - Shen, Han-Ming AU - Whiteman, Matt AU - Huang, Chuanshu PY - 2006/11/20/ UR - http://dx.doi.org/10.1083/jcb.200602149 ER -