Lineage-Specific Gene Duplication and Loss in Human and Great Ape Evolution Export

@article{citeulike:3140411, abstract = {Given that gene duplication is a major driving force of evolutionary change and the key mechanism underlying the emergence of new genes and biological processes, this study sought to use a novel genome-wide approach to identify genes that have undergone lineage-specific duplications or contractions among several hominoid lineages. Interspecies cDNA array-based comparative genomic hybridization was used to individually compare copy number variation for 39,711 cDNAs, representing 29,619 human genes, across five hominoid species, including human. We identified 1,005 genes, either as isolated genes or in clusters positionally biased toward rearrangement-prone genomic regions, that produced relative hybridization signals unique to one or more of the hominoid lineages. Measured as a function of the evolutionary age of each lineage, genes showing copy number expansions were most pronounced in human (134) and include a number of genes thought to be involved in the structure and function of the brain. This work represents, to our knowledge, the first genome-wide gene-based survey of gene duplication across hominoid species. The genes identified here likely represent a significant majority of the major gene copy number changes that have occurred over the past 15 million years of human and great ape evolution and are likely to underlie some of the key phenotypic characteristics that distinguish these species.}, author = {Fortna, Andrew and Kim, Young and Maclaren, Erik and Marshall, Kriste and Hahn, Gretchen and Meltesen, Lynne and Brenton, Matthew and Hink, Raquel and Burgers, Sonya and Hernandez-Boussard, Tina and Karimpour-Fard, Anis and Glueck, Deborah and Mcgavran, Loris and Berry, Rebecca and Pollack, Jonathan and Sikela, James M.}, citeulike-article-id = {3140411}, citeulike-linkout-0 = {http://dx.doi.org/10.1371/journal.pbio.0020207}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/15252450}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=15252450}, day = {1}, doi = {10.1371/journal.pbio.0020207}, journal = {PLoS Biology}, keywords = {cnv, primates}, month = {July}, number = {7}, pages = {e207+}, posted-at = {2008-08-20 14:47:52}, priority = {4}, title = {Lineage-Specific Gene Duplication and Loss in Human and Great Ape Evolution}, url = {http://dx.doi.org/10.1371/journal.pbio.0020207}, volume = {2}, year = {2004} }

TY - JOUR ID - citeulike:3140411 L3 - citeulike-article-id:3140411 N2 - Given that gene duplication is a major driving force of evolutionary change and the key mechanism underlying the emergence of new genes and biological processes, this study sought to use a novel genome-wide approach to identify genes that have undergone lineage-specific duplications or contractions among several hominoid lineages. Interspecies cDNA array-based comparative genomic hybridization was used to individually compare copy number variation for 39,711 cDNAs, representing 29,619 human genes, across five hominoid species, including human. We identified 1,005 genes, either as isolated genes or in clusters positionally biased toward rearrangement-prone genomic regions, that produced relative hybridization signals unique to one or more of the hominoid lineages. Measured as a function of the evolutionary age of each lineage, genes showing copy number expansions were most pronounced in human (134) and include a number of genes thought to be involved in the structure and function of the brain. This work represents, to our knowledge, the first genome-wide gene-based survey of gene duplication across hominoid species. The genes identified here likely represent a significant majority of the major gene copy number changes that have occurred over the past 15 million years of human and great ape evolution and are likely to underlie some of the key phenotypic characteristics that distinguish these species. IS - 7 JF - PLoS Biology TI - Lineage-Specific Gene Duplication and Loss in Human and Great Ape Evolution VL - 2 SP - e207 KW - cnv KW - primates AU - Fortna, Andrew AU - Kim, Young AU - Maclaren, Erik AU - Marshall, Kriste AU - Hahn, Gretchen AU - Meltesen, Lynne AU - Brenton, Matthew AU - Hink, Raquel AU - Burgers, Sonya AU - Hernandez-Boussard, Tina AU - Karimpour-Fard, Anis AU - Glueck, Deborah AU - Mcgavran, Loris AU - Berry, Rebecca AU - Pollack, Jonathan AU - Sikela, James PY - 2004/07/01/ UR - http://dx.doi.org/10.1371/journal.pbio.0020207 ER -