Peripheral B cell survival. Export

@article{Agenes2000, abstract = {Recent findings suggest that lymphocyte survival is a continuous active process and support the role of B cell receptor engagement in B cell survival. In this context the conflict of survival interests between the diverse B cells gives rise to a pattern of interactions which mimics the behavior of complex ecological systems. In response to competition lymphocytes modify their survival requirements and diverge to occupy different immunological niches through differentiation. Thus naive and memory-activated B cell populations show independent homeostatic regulation. We discuss how niche differentiation allows the coexistence of different cell types and guarantees both repertoire diversity and efficient immune responses.}, author = {Agen\`{e}s, F. and Rosado, M. M. and Freitas, A. A.}, citeulike-article-id = {2703403}, institution = {Basel Institute for Immunology, Switzerland.}, journal = {Cell Mol Life Sci}, keywords = {animals, antigen, b-cell, b-lymphocytes, cell, file-import-08-04-23, humans, immunologic, memory, receptors, survival}, month = {Aug}, number = {8-9}, pages = {1220--1228}, posted-at = {2008-04-23 01:19:35}, priority = {0}, title = {Peripheral B cell survival.}, volume = {57}, year = {2000} }

TY - JOUR ID - Agenes2000 L3 - citeulike-article-id:2703403 N2 - Recent findings suggest that lymphocyte survival is a continuous active process and support the role of B cell receptor engagement in B cell survival. In this context the conflict of survival interests between the diverse B cells gives rise to a pattern of interactions which mimics the behavior of complex ecological systems. In response to competition lymphocytes modify their survival requirements and diverge to occupy different immunological niches through differentiation. Thus naive and memory-activated B cell populations show independent homeostatic regulation. We discuss how niche differentiation allows the coexistence of different cell types and guarantees both repertoire diversity and efficient immune responses. IS - 8-9 JF - Cell Mol Life Sci EP - 1228 TI - Peripheral B cell survival. VL - 57 SP - 1220 KW - animals KW - antigen KW - b-cell KW - b-lymphocytes KW - cell KW - file-import-08-04-23 KW - humans KW - immunologic KW - memory KW - receptors KW - survival AU - Agenès, F AU - Rosado, MM AU - Freitas, AA PY - 2000/Aug// ER -