Clonal origin and evolution of a transmissible cancer. Export

@article{Murgia2006, abstract = {The transmissible agent causing canine transmissible venereal tumor (CTVT) is thought to be the tumor cell itself. To test this hypothesis, we analyzed genetic markers including major histocompatibility (MHC) genes, microsatellites, and mitochondrial DNA (mtDNA) in naturally occurring tumors and matched blood samples. In each case, the tumor is genetically distinct from its host. Moreover, tumors collected from 40 dogs in 5 continents are derived from a single neoplastic clone that has diverged into two subclades. Phylogenetic analyses indicate that CTVT most likely originated from a wolf or an East Asian breed of dog between 200 and 2500 years ago. Although CTVT is highly aneuploid, it has a remarkably stable genotype. During progressive growth, CTVT downmodulates MHC antigen expression. Our findings have implications for understanding genome instability in cancer, natural transplantation of allografts, and the capacity of a somatic cell to evolve into a transmissible parasite.}, author = {Murgia, Claudio and Pritchard, Jonathan K. and Kim, Su Y. and Fassati, Ariberto and Weiss, Robin A.}, citeulike-article-id = {2704455}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.cell.2006.05.051}, doi = {10.1016/j.cell.2006.05.051}, institution = {MRC/UCL Centre for Medical Molecular Virology, Division of Infection and Immunity, University College London, 46 Cleveland Street, London W1T 4JF, UK.}, journal = {Cell}, keywords = {aneuploidy, animal, animals, antigens, base, behavior, canidae, cell, cells, clone, data, diseases, dna, dog, dogs, down-regulation, evolution, female, file-import-08-04-23, genetic, genomic, genotype, histocompatibility, immune, instability, lineage, male, markers, microsatellite, mitochondrial, molecular, phylogeny, repeats, sequence, sexual, tolerance, tumors, venereal, veterinary}, month = {Aug}, number = {3}, pages = {477--487}, posted-at = {2008-04-23 01:20:34}, priority = {0}, title = {Clonal origin and evolution of a transmissible cancer.}, url = {http://dx.doi.org/10.1016/j.cell.2006.05.051}, volume = {126}, year = {2006} }

TY - JOUR ID - Murgia2006 L3 - citeulike-article-id:2704455 N2 - The transmissible agent causing canine transmissible venereal tumor (CTVT) is thought to be the tumor cell itself. To test this hypothesis, we analyzed genetic markers including major histocompatibility (MHC) genes, microsatellites, and mitochondrial DNA (mtDNA) in naturally occurring tumors and matched blood samples. In each case, the tumor is genetically distinct from its host. Moreover, tumors collected from 40 dogs in 5 continents are derived from a single neoplastic clone that has diverged into two subclades. Phylogenetic analyses indicate that CTVT most likely originated from a wolf or an East Asian breed of dog between 200 and 2500 years ago. Although CTVT is highly aneuploid, it has a remarkably stable genotype. During progressive growth, CTVT downmodulates MHC antigen expression. Our findings have implications for understanding genome instability in cancer, natural transplantation of allografts, and the capacity of a somatic cell to evolve into a transmissible parasite. IS - 3 JF - Cell EP - 487 TI - Clonal origin and evolution of a transmissible cancer. VL - 126 SP - 477 KW - aneuploidy KW - animal KW - animals KW - antigens KW - base KW - behavior KW - canidae KW - cell KW - cells KW - clone KW - data KW - diseases KW - dna KW - dog KW - dogs KW - down-regulation KW - evolution KW - female KW - file-import-08-04-23 KW - genetic KW - genomic KW - genotype KW - histocompatibility KW - immune KW - instability KW - lineage KW - male KW - markers KW - microsatellite KW - mitochondrial KW - molecular KW - phylogeny KW - repeats KW - sequence KW - sexual KW - tolerance KW - tumors KW - venereal KW - veterinary AU - Murgia, Claudio AU - Pritchard, Jonathan AU - Kim, Su AU - Fassati, Ariberto AU - Weiss, Robin PY - 2006/Aug// UR - http://dx.doi.org/10.1016/j.cell.2006.05.051 ER -