Uncertainties - discrepancies in immunology. Export

@article{Zinkernagel2002, abstract = {The many immunological observations and results from in-vitro or in-vivo experiments vary, and their interpretations differ enormously. A major problem is that within a normal distribution of biological phenomena, which are measurable with many methods, virtually anything is possible. Within a coevolutionary context, the definition of biologically relevant thresholds is an important key to improve our understanding of weaknesses and strengths of the immune system. This review is a personal view, comparing textbook rules and experiments using model antigens with observations on immunity against infections or tumors to critically evaluate our perception and understanding of specificity, affinity maturation, antigen presentation, selection of the class of the immune response, immunological memory and protective immunity, positive selection of T cells and self/nonself discrimination.}, author = {Zinkernagel, Rolf M.}, citeulike-article-id = {2704954}, institution = {Institute for Experimental Immunology, University Hospital, Zurich, Switzerland. rolf.zinkernagel@pty.usz.ch}, journal = {Immunol Rev}, keywords = {allergy, and, animals, antibody, antigen, antigens, b-lymphocytes, file-import-08-04-23, humans, immune, immunologic, immunological, immunology, memory, models, presentation, specificity, t-lymphocytes, tolerance}, month = {Jul}, pages = {103--125}, posted-at = {2008-04-23 01:21:04}, priority = {0}, title = {Uncertainties - discrepancies in immunology.}, volume = {185}, year = {2002} }

TY - JOUR ID - Zinkernagel2002 L3 - citeulike-article-id:2704954 N2 - The many immunological observations and results from in-vitro or in-vivo experiments vary, and their interpretations differ enormously. A major problem is that within a normal distribution of biological phenomena, which are measurable with many methods, virtually anything is possible. Within a coevolutionary context, the definition of biologically relevant thresholds is an important key to improve our understanding of weaknesses and strengths of the immune system. This review is a personal view, comparing textbook rules and experiments using model antigens with observations on immunity against infections or tumors to critically evaluate our perception and understanding of specificity, affinity maturation, antigen presentation, selection of the class of the immune response, immunological memory and protective immunity, positive selection of T cells and self/nonself discrimination. JF - Immunol Rev EP - 125 TI - Uncertainties - discrepancies in immunology. VL - 185 SP - 103 KW - allergy KW - and KW - animals KW - antibody KW - antigen KW - antigens KW - b-lymphocytes KW - file-import-08-04-23 KW - humans KW - immune KW - immunologic KW - immunological KW - immunology KW - memory KW - models KW - presentation KW - specificity KW - t-lymphocytes KW - tolerance AU - Zinkernagel, Rolf PY - 2002/Jul// ER -