Altered response control and anterior cingulate function in attention-deficit/hyperactivity disorder boys. Export

@article{citeulike:2855954, abstract = {OBJECTIVE: To investigate mechanisms and structures underlying prefrontal response control and inhibition in boys suffering from attention-deficit/hyperactivity disorder (ADHD). METHOD: Sixteen boys with ADHD and 19 healthy controls were investigated electrophysiologically during performance of a visual Go-Nogo task (Continuous Performance Test, CPT). An electrophysiological source localization method was employed to further analyze the data. RESULTS: The ADHD boys showed a significantly diminished central Nogo-P3, due to a lack of Nogo-related frontalization of the positive brain electrical field in this group. This two-dimensional effect was associated with a significantly reduced activation of the anterior cingulate cortex (ACC) in the ADHD boys in the Nogo condition of the CPT. Both groups did not significantly differ regarding the amplitude of the Nogo-N2. CONCLUSIONS: The results indicate deficits in prefrontal response control in unmedicated ADHD boys that do not seem to be specifically inhibitory in nature. A supposed dysfunction of the ACC in ADHD was confirmed.}, address = {Department for Psychiatry and Psychotherapy, University of Wuerzburg, University Hospital, Fuechsleinstrasse 15, 97080 Wuerzburg, Germany. afallgat@mail.uni-wuerzburg.de}, author = {Fallgatter, A. J. and Ehlis, A. C. and Seifert, J. and Strik, W. K. and Scheuerpflug, P. and Zillessen, K. E. and Herrmann, M. J. and Warnke, A.}, citeulike-article-id = {2855954}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.clinph.2003.11.036}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/15003781}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=15003781}, doi = {10.1016/j.clinph.2003.11.036}, issn = {1388-2457}, journal = {Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology}, keywords = {adhd, cingulate, cortex, cortical, eeg}, month = {April}, number = {4}, pages = {973--981}, posted-at = {2008-06-02 08:04:00}, priority = {2}, title = {Altered response control and anterior cingulate function in attention-deficit/hyperactivity disorder boys.}, url = {http://dx.doi.org/10.1016/j.clinph.2003.11.036}, volume = {115}, year = {2004} }

TY - JOUR ID - citeulike:2855954 L3 - citeulike-article-id:2855954 N2 - OBJECTIVE: To investigate mechanisms and structures underlying prefrontal response control and inhibition in boys suffering from attention-deficit/hyperactivity disorder (ADHD). METHOD: Sixteen boys with ADHD and 19 healthy controls were investigated electrophysiologically during performance of a visual Go-Nogo task (Continuous Performance Test, CPT). An electrophysiological source localization method was employed to further analyze the data. RESULTS: The ADHD boys showed a significantly diminished central Nogo-P3, due to a lack of Nogo-related frontalization of the positive brain electrical field in this group. This two-dimensional effect was associated with a significantly reduced activation of the anterior cingulate cortex (ACC) in the ADHD boys in the Nogo condition of the CPT. Both groups did not significantly differ regarding the amplitude of the Nogo-N2. CONCLUSIONS: The results indicate deficits in prefrontal response control in unmedicated ADHD boys that do not seem to be specifically inhibitory in nature. A supposed dysfunction of the ACC in ADHD was confirmed. IS - 4 JF - Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology SN - 1388-2457 AD - Department for Psychiatry and Psychotherapy, University of Wuerzburg, University Hospital, Fuechsleinstrasse 15, 97080 Wuerzburg, Germany. afallgat@mail.uni-wuerzburg.de EP - 981 TI - Altered response control and anterior cingulate function in attention-deficit/hyperactivity disorder boys. VL - 115 SP - 973 KW - adhd KW - cingulate KW - cortex KW - cortical KW - eeg AU - Fallgatter, AJ AU - Ehlis, AC AU - Seifert, J AU - Strik, WK AU - Scheuerpflug, P AU - Zillessen, KE AU - Herrmann, MJ AU - Warnke, A PY - 2004/04// UR - http://dx.doi.org/10.1016/j.clinph.2003.11.036 ER -