Diminished prefrontal brain function in adults with psychopathology in childhood related to attention deficit hyperactivity disorder. Export

@article{citeulike:2855956, abstract = {The aim of the present study was to investigate prefrontal brain function and cognitive response control in patients with personality disorders who either suffered or did not suffer from psychopathology related to attention deficit hyperactivity disorder (ADHD) during childhood. For this purpose, 36 psychiatric out-patients with personality disorders--24 of whom showed ADHD-related psychopathology during childhood assessed by the German short form of the Wender Utah Rating Scale--and 24 healthy controls were investigated electrophysiologically by means of a cued Go-NoGo task (Continuous Performance Test). Topographical analyses were conducted to individually quantify the NoGo anteriorisation (NGA), a neurophysiological correlate of prefrontal response control that has been suggested to reflect activation of the anterior cingulate cortex. ADHD patients exhibited a significantly reduced mean NGA and diminished amplitudes of the Global Field Power, as well as a reduced increase of fronto-central P300 amplitudes, in NoGo-trials compared with the healthy controls, whereas patients with personality disorders alone did not differ from the control group in any of the electrophysiological parameters. The results indicate that ADHD-related psychopathology is associated with prefrontal brain dysfunction, probably related to processes of response inhibition and/or cognitive response control.}, address = {Psychiatric Neurophysiology, Department of Psychiatry and Psychotherapy, University Hospital W\"{u}rzburg, F\"{u}chsleinstrasse 15, 97080 W\"{u}rzburg, Germany. afallgat@mail.uni-wuerzburg.de}, author = {Fallgatter, A. J. and Ehlis, A. C. and R\"{o}sler, M. and Strik, W. K. and Blocher, D. and Herrmann, M. J.}, citeulike-article-id = {2855956}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.pscychresns.2004.12.002}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/15766638}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=15766638}, day = {28}, doi = {10.1016/j.pscychresns.2004.12.002}, issn = {0165-1781}, journal = {Psychiatry research}, keywords = {adhd, cortex, cortical, eeg}, month = {February}, number = {2}, pages = {157--169}, posted-at = {2008-06-02 08:05:50}, priority = {2}, title = {Diminished prefrontal brain function in adults with psychopathology in childhood related to attention deficit hyperactivity disorder.}, url = {http://dx.doi.org/10.1016/j.pscychresns.2004.12.002}, volume = {138}, year = {2005} }

TY - JOUR ID - citeulike:2855956 L3 - citeulike-article-id:2855956 N2 - The aim of the present study was to investigate prefrontal brain function and cognitive response control in patients with personality disorders who either suffered or did not suffer from psychopathology related to attention deficit hyperactivity disorder (ADHD) during childhood. For this purpose, 36 psychiatric out-patients with personality disorders--24 of whom showed ADHD-related psychopathology during childhood assessed by the German short form of the Wender Utah Rating Scale--and 24 healthy controls were investigated electrophysiologically by means of a cued Go-NoGo task (Continuous Performance Test). Topographical analyses were conducted to individually quantify the NoGo anteriorisation (NGA), a neurophysiological correlate of prefrontal response control that has been suggested to reflect activation of the anterior cingulate cortex. ADHD patients exhibited a significantly reduced mean NGA and diminished amplitudes of the Global Field Power, as well as a reduced increase of fronto-central P300 amplitudes, in NoGo-trials compared with the healthy controls, whereas patients with personality disorders alone did not differ from the control group in any of the electrophysiological parameters. The results indicate that ADHD-related psychopathology is associated with prefrontal brain dysfunction, probably related to processes of response inhibition and/or cognitive response control. IS - 2 JF - Psychiatry research SN - 0165-1781 AD - Psychiatric Neurophysiology, Department of Psychiatry and Psychotherapy, University Hospital Würzburg, Füchsleinstrasse 15, 97080 Würzburg, Germany. afallgat@mail.uni-wuerzburg.de EP - 169 TI - Diminished prefrontal brain function in adults with psychopathology in childhood related to attention deficit hyperactivity disorder. VL - 138 SP - 157 KW - adhd KW - cortex KW - cortical KW - eeg AU - Fallgatter, AJ AU - Ehlis, AC AU - Rösler, M AU - Strik, WK AU - Blocher, D AU - Herrmann, MJ PY - 2005/02/28/ UR - http://dx.doi.org/10.1016/j.pscychresns.2004.12.002 ER -