Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys Export

@article{citeulike:5099716, abstract = {Caloric restriction (CR), without malnutrition, delays aging and extends life span in diverse species; however, its effect on resistance to illness and mortality in primates has not been clearly established. We report findings of a 20-year longitudinal adult-onset CR study in rhesus monkeys aimed at filling this critical gap in aging research. In a population of rhesus macaques maintained at the Wisconsin National Primate Research Center, moderate CR lowered the incidence of aging-related deaths. At the time point reported, 50\% of control fed animals survived as compared with 80\% of the CR animals. Furthermore, CR delayed the onset of age-associated pathologies. Specifically, CR reduced the incidence of diabetes, cancer, cardiovascular disease, and brain atrophy. These data demonstrate that CR slows aging in a primate species. 10.1126/science.1173635}, author = {Colman, Ricki J. and Anderson, Rozalyn M. and Johnson, Sterling C. and Kastman, Erik K. and Kosmatka, Kristopher J. and Beasley, T. Mark and Allison, David B. and Cruzen, Christina and Simmons, Heather A. and Kemnitz, Joseph W. and Weindruch, Richard}, citeulike-article-id = {5099716}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1173635}, citeulike-linkout-1 = {http://www.sciencemag.org/cgi/content/abstract/325/5937/201}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19590001}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19590001}, day = {10}, doi = {10.1126/science.1173635}, journal = {Science}, keywords = {medical, metabolism, onestar, random}, month = {July}, number = {5937}, pages = {201--204}, posted-at = {2009-08-06 22:24:21}, priority = {2}, title = {Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys}, url = {http://dx.doi.org/10.1126/science.1173635}, volume = {325}, year = {2009} }

TY - JOUR ID - citeulike:5099716 L3 - citeulike-article-id:5099716 N2 - Caloric restriction (CR), without malnutrition, delays aging and extends life span in diverse species; however, its effect on resistance to illness and mortality in primates has not been clearly established. We report findings of a 20-year longitudinal adult-onset CR study in rhesus monkeys aimed at filling this critical gap in aging research. In a population of rhesus macaques maintained at the Wisconsin National Primate Research Center, moderate CR lowered the incidence of aging-related deaths. At the time point reported, 50% of control fed animals survived as compared with 80% of the CR animals. Furthermore, CR delayed the onset of age-associated pathologies. Specifically, CR reduced the incidence of diabetes, cancer, cardiovascular disease, and brain atrophy. These data demonstrate that CR slows aging in a primate species. 10.1126/science.1173635 IS - 5937 JF - Science EP - 204 TI - Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys VL - 325 SP - 201 KW - medical KW - metabolism KW - onestar KW - random AU - Colman, Ricki AU - Anderson, Rozalyn AU - Johnson, Sterling AU - Kastman, Erik AU - Kosmatka, Kristopher AU - Beasley, Mark AU - Allison, David AU - Cruzen, Christina AU - Simmons, Heather AU - Kemnitz, Joseph AU - Weindruch, Richard PY - 2009/07/10/ UR - http://dx.doi.org/10.1126/science.1173635 ER -