Genetics of human gene expression: mapping DNA variants that influence gene expression. Export

@article{citeulike:5378367, abstract = {There is extensive natural variation in human gene expression. As quantitative phenotypes, expression levels of genes are heritable. Genetic linkage and association mapping have identified cis- and trans-acting DNA variants that influence expression levels of human genes. New insights into human gene regulation are emerging from genetic analyses of gene expression in cells at rest and following exposure to stimuli. The integration of these genetic mapping results with data from co-expression networks is leading to a better understanding of how expression levels of individual genes are regulated and how genes interact with each other. These findings are important for basic understanding of gene regulation and of diseases that result from disruption of normal gene regulation.}, author = {Cheung, Vivian G. and Spielman, Richard S.}, citeulike-article-id = {5378367}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nrg2630}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nrg2630}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19636342}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19636342}, day = {28}, doi = {10.1038/nrg2630}, issn = {1471-0064}, journal = {Nature reviews. Genetics}, keywords = {genotyping, review, threestar, transcriptomics}, month = {September}, number = {9}, pages = {595--604}, posted-at = {2009-08-18 16:37:52}, priority = {2}, publisher = {Nature Publishing Group}, title = {Genetics of human gene expression: mapping DNA variants that influence gene expression.}, url = {http://dx.doi.org/10.1038/nrg2630}, volume = {10}, year = {2009} }

TY - JOUR ID - citeulike:5378367 L3 - citeulike-article-id:5378367 N2 - There is extensive natural variation in human gene expression. As quantitative phenotypes, expression levels of genes are heritable. Genetic linkage and association mapping have identified cis- and trans-acting DNA variants that influence expression levels of human genes. New insights into human gene regulation are emerging from genetic analyses of gene expression in cells at rest and following exposure to stimuli. The integration of these genetic mapping results with data from co-expression networks is leading to a better understanding of how expression levels of individual genes are regulated and how genes interact with each other. These findings are important for basic understanding of gene regulation and of diseases that result from disruption of normal gene regulation. IS - 9 JF - Nature reviews. Genetics SN - 1471-0064 EP - 604 TI - Genetics of human gene expression: mapping DNA variants that influence gene expression. PB - Nature Publishing Group VL - 10 SP - 595 KW - genotyping KW - review KW - threestar KW - transcriptomics AU - Cheung, Vivian AU - Spielman, Richard PY - 2009/09/28/ UR - http://dx.doi.org/10.1038/nrg2630 ER -