Microfluidic devices for measuring gene network dynamics in single cells. Export

@article{citeulike:5415638, abstract = {The dynamics governing gene regulation have an important role in determining the phenotype of a cell or organism. From processing extracellular signals to generating internal rhythms, gene networks are central to many time-dependent cellular processes. Recent technological advances now make it possible to track the dynamics of gene networks in single cells under various environmental conditions using microfluidic 'lab-on-a-chip' devices, and researchers are using these new techniques to analyse cellular dynamics and discover regulatory mechanisms. These technologies are expected to yield novel insights and allow the construction of mathematical models that more accurately describe the complex dynamics of gene regulation.}, author = {Bennett, Matthew R. and Hasty, Jeff}, citeulike-article-id = {5415638}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nrg2625}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nrg2625}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19668248}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19668248}, day = {11}, doi = {10.1038/nrg2625}, issn = {1471-0064}, journal = {Nature reviews. Genetics}, keywords = {method, microfluidics, review, twostar}, month = {September}, number = {9}, pages = {628--638}, posted-at = {2009-08-18 16:40:00}, priority = {2}, publisher = {Nature Publishing Group}, title = {Microfluidic devices for measuring gene network dynamics in single cells.}, url = {http://dx.doi.org/10.1038/nrg2625}, volume = {10}, year = {2009} }

TY - JOUR ID - citeulike:5415638 L3 - citeulike-article-id:5415638 N2 - The dynamics governing gene regulation have an important role in determining the phenotype of a cell or organism. From processing extracellular signals to generating internal rhythms, gene networks are central to many time-dependent cellular processes. Recent technological advances now make it possible to track the dynamics of gene networks in single cells under various environmental conditions using microfluidic 'lab-on-a-chip' devices, and researchers are using these new techniques to analyse cellular dynamics and discover regulatory mechanisms. These technologies are expected to yield novel insights and allow the construction of mathematical models that more accurately describe the complex dynamics of gene regulation. IS - 9 JF - Nature reviews. Genetics SN - 1471-0064 EP - 638 TI - Microfluidic devices for measuring gene network dynamics in single cells. PB - Nature Publishing Group VL - 10 SP - 628 KW - method KW - microfluidics KW - review KW - twostar AU - Bennett, Matthew AU - Hasty, Jeff PY - 2009/09/11/ UR - http://dx.doi.org/10.1038/nrg2625 ER -