An Expressed Fgf4 Retrogene Is Associated with Breed-Defining Chondrodysplasia in Domestic Dogs Export

@article{citeulike:5495587, abstract = {Retrotransposition of processed mRNAs is a common source of novel sequence acquired during the evolution of genomes. Although the vast majority of retroposed gene copies, or retrogenes, rapidly accumulate debilitating mutations that disrupt the reading frame, a small percentage become new genes that encode functional proteins. By using a multibreed association analysis in the domestic dog, we demonstrate that expression of a recently acquired retrogene encoding fibroblast growth factor 4 (fgf4) is strongly associated with chondrodysplasia, a short-legged phenotype that defines at least 19 dog breeds including dachshund, corgi, and basset hound. These results illustrate the important role of a single evolutionary event in constraining and directing phenotypic diversity in the domestic dog. 10.1126/science.1173275}, author = {Parker, Heidi G. and VonHoldt, Bridgett M. and Quignon, Pascale and Margulies, Elliott H. and Shao, Stephanie and Mosher, Dana S. and Spady, Tyrone C. and Elkahloun, Abdel and Cargill, Michele and Jones, Paul G. and Maslen, Cheryl L. and Acland, Gregory M. and Sutter, Nathan B. and Kuroki, Keiichi and Bustamante, Carlos D. and Wayne, Robert K. and Ostrander, Elaine A.}, booktitle = {Science}, citeulike-article-id = {5495587}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1173275}, citeulike-linkout-1 = {http://www.sciencemag.org/cgi/content/abstract/325/5943/995}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19608863}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19608863}, day = {21}, doi = {10.1126/science.1173275}, journal = {Science}, keywords = {journalclub, linkagemapping, threestar}, month = {August}, number = {5943}, pages = {995--998}, posted-at = {2009-08-21 01:15:44}, priority = {2}, title = {An Expressed Fgf4 Retrogene Is Associated with Breed-Defining Chondrodysplasia in Domestic Dogs}, url = {http://dx.doi.org/10.1126/science.1173275}, volume = {325}, year = {2009} }

TY - JOUR ID - citeulike:5495587 L3 - citeulike-article-id:5495587 N2 - Retrotransposition of processed mRNAs is a common source of novel sequence acquired during the evolution of genomes. Although the vast majority of retroposed gene copies, or retrogenes, rapidly accumulate debilitating mutations that disrupt the reading frame, a small percentage become new genes that encode functional proteins. By using a multibreed association analysis in the domestic dog, we demonstrate that expression of a recently acquired retrogene encoding fibroblast growth factor 4 (fgf4) is strongly associated with chondrodysplasia, a short-legged phenotype that defines at least 19 dog breeds including dachshund, corgi, and basset hound. These results illustrate the important role of a single evolutionary event in constraining and directing phenotypic diversity in the domestic dog. 10.1126/science.1173275 IS - 5943 JF - Science EP - 998 TI - An Expressed Fgf4 Retrogene Is Associated with Breed-Defining Chondrodysplasia in Domestic Dogs VL - 325 T2 - Science SP - 995 KW - journalclub KW - linkagemapping KW - threestar AU - Parker, Heidi AU - VonHoldt, Bridgett AU - Quignon, Pascale AU - Margulies, Elliott AU - Shao, Stephanie AU - Mosher, Dana AU - Spady, Tyrone AU - Elkahloun, Abdel AU - Cargill, Michele AU - Jones, Paul AU - Maslen, Cheryl AU - Acland, Gregory AU - Sutter, Nathan AU - Kuroki, Keiichi AU - Bustamante, Carlos AU - Wayne, Robert AU - Ostrander, Elaine PY - 2009/08/21/ UR - http://dx.doi.org/10.1126/science.1173275 ER -