Candidate gene for the chromosome 1 familial Alzheimer's disease locus. Export

@article{citeulike:1580491, abstract = {A candidate gene for the chromosome 1 Alzheimer's disease (AD) locus was identified (STM2). The predicted amino acid sequence for STM2 is homologous to that of the recently cloned chromosome 14 AD gene (S182). A point mutation in STM2, resulting in the substitution of an isoleucine for an asparagine (N141l), was identified in affected people from Volga German AD kindreds. This N141l mutation occurs at an amino acid residue that is conserved in human S182 and in the mouse S182 homolog. The presence of missense mutations in AD subjects in two highly similar genes strongly supports the hypothesis that mutations in both are pathogenic.}, address = {Geriatric Research Education, and Clinical Center (182B), Veterans Affairs Medical Center, Seattle, WA 98108, USA.}, author = {Levy-Lahad, E. and Wasco, W. and Poorkaj, P. and Romano, D. M. and Oshima, J. and Pettingell, W. H. and Yu, C. E. and Jondro, P. D. and Schmidt, S. D. and Wang, K.}, citeulike-article-id = {1580491}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/7638622}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=7638622}, issn = {0036-8075}, journal = {Science}, keywords = {alzheimers, brain, fad, genetics, pathogenesis, presenilin}, month = {August}, number = {5226}, pages = {973--977}, posted-at = {2007-08-21 16:54:02}, priority = {0}, title = {Candidate gene for the chromosome 1 familial Alzheimer's disease locus.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/7638622}, volume = {269}, year = {1995} }

TY - JOUR ID - citeulike:1580491 L3 - citeulike-article-id:1580491 N2 - A candidate gene for the chromosome 1 Alzheimer's disease (AD) locus was identified (STM2). The predicted amino acid sequence for STM2 is homologous to that of the recently cloned chromosome 14 AD gene (S182). A point mutation in STM2, resulting in the substitution of an isoleucine for an asparagine (N141l), was identified in affected people from Volga German AD kindreds. This N141l mutation occurs at an amino acid residue that is conserved in human S182 and in the mouse S182 homolog. The presence of missense mutations in AD subjects in two highly similar genes strongly supports the hypothesis that mutations in both are pathogenic. IS - 5226 JF - Science SN - 0036-8075 AD - Geriatric Research Education, and Clinical Center (182B), Veterans Affairs Medical Center, Seattle, WA 98108, USA. EP - 977 TI - Candidate gene for the chromosome 1 familial Alzheimer's disease locus. VL - 269 SP - 973 KW - alzheimers KW - brain KW - fad KW - genetics KW - pathogenesis KW - presenilin AU - Levy-Lahad, E AU - Wasco, W AU - Poorkaj, P AU - Romano, DM AU - Oshima, J AU - Pettingell, WH AU - Yu, CE AU - Jondro, PD AU - Schmidt, SD AU - Wang, K PY - 1995/08/18/ UR - http://view.ncbi.nlm.nih.gov/pubmed/7638622 ER -