Deep gray matter atrophy in multiple sclerosis: a tensor based morphometry. Export

@article{citeulike:4494283, abstract = {Tensor based morphometry (TBM) was applied to determine the atrophy of deep gray matter (DGM) structures in 88 relapsing multiple sclerosis (MS) patients. For group analysis of atrophy, an unbiased atlas was constructed from 20 normal brains. The MS brain images were co-registered with the unbiased atlas using a symmetric inverse consistent nonlinear registration. These studies demonstrate significant atrophy of thalamus, caudate nucleus, and putamen even at a modest clinical disability, as assessed by the expanded disability status score (EDSS). A significant correlation between atrophy and EDSS was observed for different DGM structures: (thalamus: r=-0.51, p=3.85 x 10(-7); caudate nucleus: r=-0.43, p=2.35 x 10(-5); putamen: r=-0.36, p=6.12 x 10(-6)). Atrophy of these structures also correlated with 1) T2 hyperintense lesion volumes (thalamus: r=-0.56, p=9.96 x 10(-9); caudate nucleus: r=-0.31, p=3.10 x 10(-3); putamen: r=-0.50, p=6.06 x 10(-7)), 2) T1 hypointense lesion volumes (thalamus: r=-0.61, p=2.29 x 10(-10); caudate nucleus: r=-0.35, p=9.51 x 10(-4); putamen: r=-0.43, p=3.51 x 10(-5)), and 3) normalized CSF volume (thalamus: r=-0.66, p=3.55 x 10(-12); caudate nucleus: r=-0.52, p=2.31 x 10(-7), and putamen: r=-0.66, r=2.13 x 10(-12)). More severe atrophy was observed mainly in thalamus at higher EDSS. These studies appear to suggest a link between the white matter damage and DGM atrophy in MS.}, author = {Tao, Guozhi and Datta, Sushmita and He, Renjie and Nelson, Flavia and Wolinsky, Jerry S. and Narayana, Ponnada A.}, citeulike-article-id = {4494283}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.jns.2008.12.035}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S0022510X08006692}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19168189}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19168189}, day = {15}, doi = {10.1016/j.jns.2008.12.035}, issn = {1878-5883}, journal = {Journal of the neurological sciences}, keywords = {atrophy, brain, dbm, gm, human, imaging, morphometry, multiple-sclerosis, neuroanatomy, structural, tbm}, month = {July}, number = {1-2}, pages = {39--46}, posted-at = {2009-08-25 21:31:38}, priority = {2}, title = {Deep gray matter atrophy in multiple sclerosis: a tensor based morphometry.}, url = {http://dx.doi.org/10.1016/j.jns.2008.12.035}, volume = {282}, year = {2009} }

TY - JOUR ID - citeulike:4494283 L3 - citeulike-article-id:4494283 N2 - Tensor based morphometry (TBM) was applied to determine the atrophy of deep gray matter (DGM) structures in 88 relapsing multiple sclerosis (MS) patients. For group analysis of atrophy, an unbiased atlas was constructed from 20 normal brains. The MS brain images were co-registered with the unbiased atlas using a symmetric inverse consistent nonlinear registration. These studies demonstrate significant atrophy of thalamus, caudate nucleus, and putamen even at a modest clinical disability, as assessed by the expanded disability status score (EDSS). A significant correlation between atrophy and EDSS was observed for different DGM structures: (thalamus: r=-0.51, p=3.85 x 10(-7); caudate nucleus: r=-0.43, p=2.35 x 10(-5); putamen: r=-0.36, p=6.12 x 10(-6)). Atrophy of these structures also correlated with 1) T2 hyperintense lesion volumes (thalamus: r=-0.56, p=9.96 x 10(-9); caudate nucleus: r=-0.31, p=3.10 x 10(-3); putamen: r=-0.50, p=6.06 x 10(-7)), 2) T1 hypointense lesion volumes (thalamus: r=-0.61, p=2.29 x 10(-10); caudate nucleus: r=-0.35, p=9.51 x 10(-4); putamen: r=-0.43, p=3.51 x 10(-5)), and 3) normalized CSF volume (thalamus: r=-0.66, p=3.55 x 10(-12); caudate nucleus: r=-0.52, p=2.31 x 10(-7), and putamen: r=-0.66, r=2.13 x 10(-12)). More severe atrophy was observed mainly in thalamus at higher EDSS. These studies appear to suggest a link between the white matter damage and DGM atrophy in MS. IS - 1-2 JF - Journal of the neurological sciences SN - 1878-5883 EP - 46 TI - Deep gray matter atrophy in multiple sclerosis: a tensor based morphometry. VL - 282 SP - 39 KW - atrophy KW - brain KW - dbm KW - gm KW - human KW - imaging KW - morphometry KW - multiple-sclerosis KW - neuroanatomy KW - structural KW - tbm AU - Tao, Guozhi AU - Datta, Sushmita AU - He, Renjie AU - Nelson, Flavia AU - Wolinsky, Jerry AU - Narayana, Ponnada PY - 2009/07/15/ UR - http://dx.doi.org/10.1016/j.jns.2008.12.035 ER -