Genetic dissection of the mouse CNS using magnetic resonance microscopy. Export

@article{citeulike:5955165, abstract = {PURPOSE OF REVIEW: Advances in magnetic resonance microscopy (MRM) make it practical to map gene variants responsible for structural variation in brains of many species, including mice and humans. We review results of a systematic genetic analysis of MRM data using as a case study a family of well characterized lines of mice. RECENT ADVANCES: MRM has matured to the point that we can generate high contrast, high-resolution images even for species as small as a mouse, with a brain merely 1/3000th the size of humans. We generated 21.5-micron data sets for a diverse panel of BXD mouse strains to gauge the extent of genetic variation, and as a prelude to comprehensive genetic and genomic analyses. Here we review MRM capabilities and image segmentation methods; heritability of brain variation; covariation of the sizes of brain regions; and correlations between MRM and classical histological data sets. SUMMARY: The combination of high throughput MRM and genomics will improve our understanding of the genetic basis of structure-function correlations. Sophisticated mouse models will be critical in converting correlations into mechanisms and in determining genetic and epigenetic causes of differences in disease susceptibility.}, author = {Badea, Alexandra and Johnson, G. Allan and Williams, Robert W.}, citeulike-article-id = {5955165}, citeulike-linkout-0 = {http://dx.doi.org/10.1097/WCO.0b013e32832d9b86}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/19542887}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=19542887}, doi = {10.1097/WCO.0b013e32832d9b86}, issn = {1473-6551}, journal = {Current opinion in neurology}, keywords = {alzheimers, brain, dbm, genetics, imaging, morphometry, mouse, neurodegenerative, review, vbm}, month = {August}, number = {4}, pages = {379--386}, posted-at = {2009-10-17 02:25:48}, priority = {0}, title = {Genetic dissection of the mouse CNS using magnetic resonance microscopy.}, url = {http://dx.doi.org/10.1097/WCO.0b013e32832d9b86}, volume = {22}, year = {2009} }

TY - JOUR ID - citeulike:5955165 L3 - citeulike-article-id:5955165 N2 - PURPOSE OF REVIEW: Advances in magnetic resonance microscopy (MRM) make it practical to map gene variants responsible for structural variation in brains of many species, including mice and humans. We review results of a systematic genetic analysis of MRM data using as a case study a family of well characterized lines of mice. RECENT ADVANCES: MRM has matured to the point that we can generate high contrast, high-resolution images even for species as small as a mouse, with a brain merely 1/3000th the size of humans. We generated 21.5-micron data sets for a diverse panel of BXD mouse strains to gauge the extent of genetic variation, and as a prelude to comprehensive genetic and genomic analyses. Here we review MRM capabilities and image segmentation methods; heritability of brain variation; covariation of the sizes of brain regions; and correlations between MRM and classical histological data sets. SUMMARY: The combination of high throughput MRM and genomics will improve our understanding of the genetic basis of structure-function correlations. Sophisticated mouse models will be critical in converting correlations into mechanisms and in determining genetic and epigenetic causes of differences in disease susceptibility. IS - 4 JF - Current opinion in neurology SN - 1473-6551 EP - 386 TI - Genetic dissection of the mouse CNS using magnetic resonance microscopy. VL - 22 SP - 379 KW - alzheimers KW - brain KW - dbm KW - genetics KW - imaging KW - morphometry KW - mouse KW - neurodegenerative KW - review KW - vbm AU - Badea, Alexandra AU - Johnson, Allan AU - Williams, Robert PY - 2009/08// UR - http://dx.doi.org/10.1097/WCO.0b013e32832d9b86 ER -