Predicting the time of conversion to MCI in the elderly: Role of verbal expression and learning Export

@article{citeulike:6060394, abstract = {Background: Increasing awareness that minimal or mild cognitive impairment (MCI) in the elderly may be a precursor of dementia has led to an increase in the number of people attending memory clinics. We aimed to develop a way of predicting the period of time before cognitive impairment occurs in community-dwelling elderly. The method is illustrated by the use of simple tests of different cognitive domains. Methods: A cohort of 241 normal elderly volunteers was followed for up to 20 years with regular assessments of cognitive abilities using the Cambridge Cognitive Examination (CAMCOG); 91 participants developed MCI. We used interval-censored survival analysis statistical methods to model which baseline cognitive tests best predicted the time to convert to MCI. Results: Out of several baseline variables, only age and CAMCOG subscores for expression and learning/memory were predictors of the time to conversion. The time to conversion was 14\% shorter for each 5 years of age, 17\% shorter for each point lower in the expression score, and 15\% shorter for each point lower in the learning score. We present in tabular form the probability of converting to MCI over intervals between 2 and 10 years for different combinations of expression and learning scores. Conclusion: In apparently normal elderly people, subtle measurable cognitive deficits that occur within the normal range on standard testing protocols reliably predict the time to clinically relevant cognitive impairment long before clinical symptoms are reported. 10.1212/WNL.0b013e3181c0665f}, author = {Oulhaj, Abderrahim and Wilcock, Gordon K. and Smith, A. David and de Jager, Celeste A.}, citeulike-article-id = {6060394}, citeulike-linkout-0 = {http://dx.doi.org/10.1212/WNL.0b013e3181c0665f}, citeulike-linkout-1 = {http://www.neurology.org/content/73/18/1436.abstract}, citeulike-linkout-2 = {http://www.neurology.org/content/73/18/1436.full.pdf}, citeulike-linkout-3 = {http://view.ncbi.nlm.nih.gov/pubmed/19794124}, citeulike-linkout-4 = {http://www.hubmed.org/display.cgi?uids=19794124}, day = {3}, doi = {10.1212/WNL.0b013e3181c0665f}, journal = {Neurology}, keywords = {aging, alzheimers, brain, cognition, human, language, learning, longitudinal, mci, neurodegenerative, plasticity}, month = {November}, number = {18}, pages = {1436--1442}, posted-at = {2009-11-03 14:47:28}, priority = {3}, title = {Predicting the time of conversion to MCI in the elderly: Role of verbal expression and learning}, url = {http://dx.doi.org/10.1212/WNL.0b013e3181c0665f}, volume = {73}, year = {2009} }

TY - JOUR ID - citeulike:6060394 L3 - citeulike-article-id:6060394 N2 - Background: Increasing awareness that minimal or mild cognitive impairment (MCI) in the elderly may be a precursor of dementia has led to an increase in the number of people attending memory clinics. We aimed to develop a way of predicting the period of time before cognitive impairment occurs in community-dwelling elderly. The method is illustrated by the use of simple tests of different cognitive domains. Methods: A cohort of 241 normal elderly volunteers was followed for up to 20 years with regular assessments of cognitive abilities using the Cambridge Cognitive Examination (CAMCOG); 91 participants developed MCI. We used interval-censored survival analysis statistical methods to model which baseline cognitive tests best predicted the time to convert to MCI. Results: Out of several baseline variables, only age and CAMCOG subscores for expression and learning/memory were predictors of the time to conversion. The time to conversion was 14% shorter for each 5 years of age, 17% shorter for each point lower in the expression score, and 15% shorter for each point lower in the learning score. We present in tabular form the probability of converting to MCI over intervals between 2 and 10 years for different combinations of expression and learning scores. Conclusion: In apparently normal elderly people, subtle measurable cognitive deficits that occur within the normal range on standard testing protocols reliably predict the time to clinically relevant cognitive impairment long before clinical symptoms are reported. 10.1212/WNL.0b013e3181c0665f IS - 18 JF - Neurology EP - 1442 TI - Predicting the time of conversion to MCI in the elderly: Role of verbal expression and learning VL - 73 SP - 1436 KW - aging KW - alzheimers KW - brain KW - cognition KW - human KW - language KW - learning KW - longitudinal KW - mci KW - neurodegenerative KW - plasticity AU - Oulhaj, Abderrahim AU - Wilcock, Gordon AU - Smith, David AU - de Jager, Celeste PY - 2009/11/03/ UR - http://dx.doi.org/10.1212/WNL.0b013e3181c0665f ER -