Imaging subcortical auditory activity in humans Export

@article{citeulike:842426, abstract = {There is a lack of physiological data pertaining to how listening humans process auditory information. Functional magnetic resonance imaging (fMRI) has provided some data for the auditory cortex in awake humans, but there is still a paucity of comparable data for subcortical auditory areas where the early stages of processing take place, as amply demonstrated by single-unit studies in animals. It is unclear why fMRI has been unsuccessful in imaging auditory brain-stem activity, but one problem may be cardiac-related, pulsatile brain-stem motion. To examine this, a method eliminating such motion (using cardiac gating) was applied to map sound-related activity in the auditory cortices and inferior colliculi in the brain stem. Activation in both the colliculi and cortex became more discernible when gating was used. In contrast with the cortex, the improvement in the colliculi resulted from a reduction in signal variability, rather than from an increase in percent signal change. This reduction is consistent with the hypothesis that motion or pulsatile flow is a major factor in brain-stem imaging. The way now seems clear to studying activity throughout the human auditory pathway in listening humans. Hum. Brain Mapping 6:33-41, 1998. {\copyright} 1998 Wiley-Liss, Inc.}, address = {MGH-NMR Center, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts 02129; Harvard-Massachusetts Institute of Technology Division of Health, Sciences and Technology, Cambridge, Massachusetts 02139; Eaton-Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139}, author = {Guimaraes, A. R. and Melcher, J. R. and Talavage, T. M. and Baker, J. R. and Ledden, P. and Rosen, B. R. and Kiang, N. Y. S. and Fullerton, B. C. and Weisskoff, R. M.}, citeulike-article-id = {842426}, citeulike-linkout-0 = {http://dx.doi.org/10.1002/(SICI)1097-0193(1998)6:1%3C33::AID-HBM3%3E3.0.CO;2-M}, citeulike-linkout-1 = {http://www3.interscience.wiley.com/cgi-bin/abstract/38755/ABSTRACT}, doi = {10.1002/(SICI)1097-0193(1998)6:1%3C33::AID-HBM3%3E3.0.CO;2-M}, journal = {Human Brain Mapping}, keywords = {fmri, gating, human}, number = {1}, pages = {33--41}, posted-at = {2006-09-14 00:47:19}, priority = {2}, title = {Imaging subcortical auditory activity in humans}, url = {http://dx.doi.org/10.1002/(SICI)1097-0193(1998)6:1%3C33::AID-HBM3%3E3.0.CO;2-M}, volume = {6}, year = {1998} }

TY - JOUR ID - citeulike:842426 L3 - citeulike-article-id:842426 N2 - There is a lack of physiological data pertaining to how listening humans process auditory information. Functional magnetic resonance imaging (fMRI) has provided some data for the auditory cortex in awake humans, but there is still a paucity of comparable data for subcortical auditory areas where the early stages of processing take place, as amply demonstrated by single-unit studies in animals. It is unclear why fMRI has been unsuccessful in imaging auditory brain-stem activity, but one problem may be cardiac-related, pulsatile brain-stem motion. To examine this, a method eliminating such motion (using cardiac gating) was applied to map sound-related activity in the auditory cortices and inferior colliculi in the brain stem. Activation in both the colliculi and cortex became more discernible when gating was used. In contrast with the cortex, the improvement in the colliculi resulted from a reduction in signal variability, rather than from an increase in percent signal change. This reduction is consistent with the hypothesis that motion or pulsatile flow is a major factor in brain-stem imaging. The way now seems clear to studying activity throughout the human auditory pathway in listening humans. Hum. Brain Mapping 6:33-41, 1998. © 1998 Wiley-Liss, Inc. IS - 1 JF - Human Brain Mapping AD - MGH-NMR Center, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts 02129; Harvard-Massachusetts Institute of Technology Division of Health, Sciences and Technology, Cambridge, Massachusetts 02139; Eaton-Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 EP - 41 TI - Imaging subcortical auditory activity in humans VL - 6 SP - 33 KW - fmri KW - gating KW - human AU - Guimaraes, AR AU - Melcher, JR AU - Talavage, TM AU - Baker, JR AU - Ledden, P AU - Rosen, BR AU - Kiang, NYS AU - Fullerton, BC AU - Weisskoff, RM PY - 1998/// UR - http://dx.doi.org/10.1002/(SICI)1097-0193(1998)6:1%3C33::AID-HBM3%3E3.0.CO;2-M ER -