Exercise, APOE, and working memory: MEG and behavioral evidence for benefit of exercise in epsilon4 carriers Export

@article{citeulike:2997641, abstract = {Performance on the Sternberg working memory task, and MEG cortical response on a variation of the Sternberg task were examined in middle-aged carriers and non-carriers of the APOE [var epsilon]4 allele. Physical activity was also assessed to examine whether exercise level modifies the relationship between APOE genotype and neurocognitive function. Regression revealed that high physical activity was associated with faster RT in the six- and eight-letter conditions of the Sternberg in [var epsilon]4 carriers, but not in the non-carriers after controlling for age, gender, and education (N = 54). Furthermore, the MEG analysis revealed that sedentary [var epsilon]4 carriers exhibited lower right temporal lobe activation on matching probe trials relative to high-active [var epsilon]4 carriers, while physical activity did not distinguish non-carriers (N = 23). The M170 peak was identified as a potential marker for pre-clinical decline as [var epsilon]4 carriers exhibited longer M170 latency, and highly physically active participants exhibited greater M170 amplitude to matching probe trials.}, author = {Deeny, Sean P. and Poeppel, David and Zimmerman, Jo B. and Roth, Stephen M. and Brandauer, Josef and Witkowski, Sarah and Hearn, Joseph W. and Ludlow, Andrew T. and Contreras-Vidal, Jos\'{e} L. and Brandt, Jason and Hatfield, Bradley D.}, citeulike-article-id = {2997641}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.biopsycho.2008.02.007}, citeulike-linkout-1 = {http://www.sciencedirect.com/science/article/B6T4T-4RYNMJB-1/1/2c733ead1ba0c04b3606f5c2bbc82541}, doi = {10.1016/j.biopsycho.2008.02.007}, journal = {Biological Psychology}, keywords = {alzheimers, apoe, exercise}, month = {May}, number = {2}, pages = {179--187}, posted-at = {2008-07-14 01:06:30}, priority = {2}, title = {Exercise, APOE, and working memory: MEG and behavioral evidence for benefit of exercise in epsilon4 carriers}, url = {http://dx.doi.org/10.1016/j.biopsycho.2008.02.007}, volume = {78}, year = {2008} }

TY - JOUR ID - citeulike:2997641 L3 - citeulike-article-id:2997641 N2 - Performance on the Sternberg working memory task, and MEG cortical response on a variation of the Sternberg task were examined in middle-aged carriers and non-carriers of the APOE [var epsilon]4 allele. Physical activity was also assessed to examine whether exercise level modifies the relationship between APOE genotype and neurocognitive function. Regression revealed that high physical activity was associated with faster RT in the six- and eight-letter conditions of the Sternberg in [var epsilon]4 carriers, but not in the non-carriers after controlling for age, gender, and education (N = 54). Furthermore, the MEG analysis revealed that sedentary [var epsilon]4 carriers exhibited lower right temporal lobe activation on matching probe trials relative to high-active [var epsilon]4 carriers, while physical activity did not distinguish non-carriers (N = 23). The M170 peak was identified as a potential marker for pre-clinical decline as [var epsilon]4 carriers exhibited longer M170 latency, and highly physically active participants exhibited greater M170 amplitude to matching probe trials. IS - 2 JF - Biological Psychology EP - 187 TI - Exercise, APOE, and working memory: MEG and behavioral evidence for benefit of exercise in epsilon4 carriers VL - 78 SP - 179 KW - alzheimers KW - apoe KW - exercise AU - Deeny, Sean AU - Poeppel, David AU - Zimmerman, Jo AU - Roth, Stephen AU - Brandauer, Josef AU - Witkowski, Sarah AU - Hearn, Joseph AU - Ludlow, Andrew AU - Contreras-Vidal, José AU - Brandt, Jason AU - Hatfield, Bradley PY - 2008/05// UR - http://dx.doi.org/10.1016/j.biopsycho.2008.02.007 ER -