Walking flexibility after hemispherectomy: split-belt treadmill adaptation and feedback control Export

@article{citeulike:3893416, abstract = {Walking flexibility depends on use of feedback or reactive control to respond to unexpected changes in the environment, and the ability to adapt feedforward or predictive control for sustained alterations. Recent work has demonstrated that cerebellar damage impairs feedforward adaptation, but not feedback control, during human split-belt treadmill walking. In contrast, focal cerebral damage from stroke did not impair either process. This led to the suggestion that cerebellar interactions with the brainstem are more important than those with cerebral structures for feedforward adaptation. Does complete removal of a cerebral hemisphere affect either of these processes? We studied split-belt walking in 10 children and adolescents (age 6-18 years) with hemispherectomy (i.e. surgical removal of one entire cerebral hemisphere) and 10 age- and sex-matched control subjects. Hemispherectomy did not impair reactive feedback control, though feedforward adaptation was impaired in some subjects. Specifically, some showed reduced or absent adaptation of inter-leg timing, whereas adaptation of spatial control was intact. These results suggest that the cerebrum is involved in adaptation of the timing, but not spatial, elements of limb movements. 10.1093/brain/awn333}, author = {Choi, Julia T. and Vining, Eileen P. and Reisman, Darcy S. and Bastian, Amy J.}, citeulike-article-id = {3893416}, citeulike-linkout-0 = {http://dx.doi.org/10.1093/brain/awn333}, citeulike-linkout-1 = {http://brain.oxfordjournals.org/cgi/content/abstract/132/3/722?ct=ct}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19074191}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19074191}, day = {11}, doi = {10.1093/brain/awn333}, journal = {Brain}, keywords = {adaptation, cerebellum, cerebral, children, cortex, feedback, feedforward, hemispherectomy, locomotion, walk}, month = {December}, pages = {awn333+}, posted-at = {2009-04-02 14:41:24}, priority = {2}, title = {Walking flexibility after hemispherectomy: split-belt treadmill adaptation and feedback control}, url = {http://dx.doi.org/10.1093/brain/awn333}, year = {2008} }

TY - JOUR ID - citeulike:3893416 L3 - citeulike-article-id:3893416 N2 - Walking flexibility depends on use of feedback or reactive control to respond to unexpected changes in the environment, and the ability to adapt feedforward or predictive control for sustained alterations. Recent work has demonstrated that cerebellar damage impairs feedforward adaptation, but not feedback control, during human split-belt treadmill walking. In contrast, focal cerebral damage from stroke did not impair either process. This led to the suggestion that cerebellar interactions with the brainstem are more important than those with cerebral structures for feedforward adaptation. Does complete removal of a cerebral hemisphere affect either of these processes? We studied split-belt walking in 10 children and adolescents (age 6-18 years) with hemispherectomy (i.e. surgical removal of one entire cerebral hemisphere) and 10 age- and sex-matched control subjects. Hemispherectomy did not impair reactive feedback control, though feedforward adaptation was impaired in some subjects. Specifically, some showed reduced or absent adaptation of inter-leg timing, whereas adaptation of spatial control was intact. These results suggest that the cerebrum is involved in adaptation of the timing, but not spatial, elements of limb movements. 10.1093/brain/awn333 JF - Brain TI - Walking flexibility after hemispherectomy: split-belt treadmill adaptation and feedback control SP - awn333 KW - adaptation KW - cerebellum KW - cerebral KW - children KW - cortex KW - feedback KW - feedforward KW - hemispherectomy KW - locomotion KW - walk AU - Choi, Julia AU - Vining, Eileen AU - Reisman, Darcy AU - Bastian, Amy PY - 2008/12/11/ UR - http://dx.doi.org/10.1093/brain/awn333 ER -