Neural correlates of motor dysfunction in children with traumatic brain injury: exploration of compensatory recruitment patterns Export

@article{citeulike:4257704, abstract = {Traumatic brain injury (TBI) is a common form of disability in children. Persistent deficits in motor control have been documented following TBI but there has been less emphasis on changes in functional cerebral activity. In the present study, children with moderate to severe TBI (n = 9) and controls (n = 17) were scanned while performing cyclical movements with their dominant and non-dominant hand and foot according to the easy isodirectional (same direction) and more difficult non-isodirectional (opposite direction) mode. Even though the children with TBI were shown to be less successful on various items of a clinical motor test battery than the control group, performance on the coordination task during scanning was similar between groups, allowing a meaningful interpretation of their brain activation differences. fMRI analysis revealed that the TBI children showed enhanced activity in medial and anterior parietal areas as well as posterior cerebellum as compared with the control group. Brain activation generally increased during the non-isodirectional as compared with the isodirectional mode and additional regions were involved, consistent with their differential degree of difficulty. However, this effect did not interact with group. Overall, the findings indicate that motor impairment in TBI children is associated with changes in functional cerebral activity, i.e. they exhibit compensatory activation reflecting increased recruitment of neural resources for attentional deployment and somatosensory processing. 10.1093/brain/awn344}, author = {Caeyenberghs, K. and Wenderoth, N. and Smits-Engelsman, B. C. M. and Sunaert, S. and Swinnen, S. P.}, citeulike-article-id = {4257704}, citeulike-linkout-0 = {http://dx.doi.org/10.1093/brain/awn344}, citeulike-linkout-1 = {http://brain.oxfordjournals.org/cgi/content/abstract/132/3/684?ct=ct}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19153150}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19153150}, day = {1}, doi = {10.1093/brain/awn344}, journal = {Brain}, keywords = {brain, cerebral, children, cortex, cycling, dysfunction, fmri, tbi}, month = {March}, number = {3}, pages = {684--694}, posted-at = {2009-04-02 14:43:37}, priority = {2}, title = {Neural correlates of motor dysfunction in children with traumatic brain injury: exploration of compensatory recruitment patterns}, url = {http://dx.doi.org/10.1093/brain/awn344}, volume = {132}, year = {2009} }

TY - JOUR ID - citeulike:4257704 L3 - citeulike-article-id:4257704 N2 - Traumatic brain injury (TBI) is a common form of disability in children. Persistent deficits in motor control have been documented following TBI but there has been less emphasis on changes in functional cerebral activity. In the present study, children with moderate to severe TBI (n = 9) and controls (n = 17) were scanned while performing cyclical movements with their dominant and non-dominant hand and foot according to the easy isodirectional (same direction) and more difficult non-isodirectional (opposite direction) mode. Even though the children with TBI were shown to be less successful on various items of a clinical motor test battery than the control group, performance on the coordination task during scanning was similar between groups, allowing a meaningful interpretation of their brain activation differences. fMRI analysis revealed that the TBI children showed enhanced activity in medial and anterior parietal areas as well as posterior cerebellum as compared with the control group. Brain activation generally increased during the non-isodirectional as compared with the isodirectional mode and additional regions were involved, consistent with their differential degree of difficulty. However, this effect did not interact with group. Overall, the findings indicate that motor impairment in TBI children is associated with changes in functional cerebral activity, i.e. they exhibit compensatory activation reflecting increased recruitment of neural resources for attentional deployment and somatosensory processing. 10.1093/brain/awn344 IS - 3 JF - Brain EP - 694 TI - Neural correlates of motor dysfunction in children with traumatic brain injury: exploration of compensatory recruitment patterns VL - 132 SP - 684 KW - brain KW - cerebral KW - children KW - cortex KW - cycling KW - dysfunction KW - fmri KW - tbi AU - Caeyenberghs, K AU - Wenderoth, N AU - Smits-Engelsman, BCM AU - Sunaert, S AU - Swinnen, SP PY - 2009/03/01/ UR - http://dx.doi.org/10.1093/brain/awn344 ER -