Brain activation of patients with obsessive-compulsive disorder during neuropsychological and symptom provocation tasks before and after symptom improvement: A functional magnetic resonance imaging study Export

@article{citeulike:1307806, abstract = {Background Functional neuroimaging studies have implicated hyperactivity of the frontal cortex in obsessive-compulsive disorder (OCD); however, relationships between abnormal brain activity, clinical improvement, and neuropsychological function have not been clarified in OCD. To clarify the pathophysiology of this disorder, regional changes in brain function were examined during administration of cognitive and symptom provocation tasks in patients with OCD before and after treatment.Methods Ten outpatients with OCD participated in the study. Functional magnetic resonance imaging (fMRI) was performed before and after treatment. Stroop and symptom provocation tasks were administered during fMRI. Each patient was randomly allocated to receive either pharmacotherapy with fluvoxamine 200 mg/day (n = 4) or behavior therapy (n = 6) for 12 weeks.Results After 12-week treatment, mean (+/- SD) total score on the Yale-Brown Obsessive-Compulsive Scale decreased from 29.00 +/- 3.59 to 14.60 +/- 9.22, representing symptomatic improvement from moderate to mild. After symptom improvement, symptom provocation-related activation in the orbitofrontal, dorsolateral-prefrontal, and anterior cingulate cortices decreased. Conversely, Stroop task-related activation in the parietal cortex and cerebellum increased.Conclusions After improvement of OCD with either fluvoxamine or behavioral therapy, hyperactivation of the frontal lobe related to a symptom-provocative state decreases, and posterior brain activity related to action-monitoring function increases.}, author = {Nakao, Tomohiro and Nakagawa, Akiko and Yoshiura, Takashi and Nakatani, Eriko and Nabeyama, Maiko and Yoshizato, Chika and Kudoh, Akiko and Tada, Kyoko and Yoshioka, Kazuko and Kawamoto, Midori and Togao, Osamu and Kanba, Shigenobu}, citeulike-article-id = {1307806}, citeulike-linkout-0 = {http://www.sciencedirect.com/science/article/B6T4S-4FNCW34-2/2/fb98424add8bd247561e78ad5c142955}, journal = {Biological Psychiatry}, keywords = {cbt, fmri, ocd, pharmacotherapy, psychotherapy, treatment}, month = {April}, number = {8}, pages = {901--910}, posted-at = {2007-05-19 06:17:19}, priority = {2}, title = {Brain activation of patients with obsessive-compulsive disorder during neuropsychological and symptom provocation tasks before and after symptom improvement: A functional magnetic resonance imaging study}, url = {http://www.sciencedirect.com/science/article/B6T4S-4FNCW34-2/2/fb98424add8bd247561e78ad5c142955}, volume = {57}, year = {2005} }

TY - JOUR ID - citeulike:1307806 L3 - citeulike-article-id:1307806 N2 - Background Functional neuroimaging studies have implicated hyperactivity of the frontal cortex in obsessive-compulsive disorder (OCD); however, relationships between abnormal brain activity, clinical improvement, and neuropsychological function have not been clarified in OCD. To clarify the pathophysiology of this disorder, regional changes in brain function were examined during administration of cognitive and symptom provocation tasks in patients with OCD before and after treatment.Methods Ten outpatients with OCD participated in the study. Functional magnetic resonance imaging (fMRI) was performed before and after treatment. Stroop and symptom provocation tasks were administered during fMRI. Each patient was randomly allocated to receive either pharmacotherapy with fluvoxamine 200 mg/day (n = 4) or behavior therapy (n = 6) for 12 weeks.Results After 12-week treatment, mean (+/- SD) total score on the Yale-Brown Obsessive-Compulsive Scale decreased from 29.00 +/- 3.59 to 14.60 +/- 9.22, representing symptomatic improvement from moderate to mild. After symptom improvement, symptom provocation-related activation in the orbitofrontal, dorsolateral-prefrontal, and anterior cingulate cortices decreased. Conversely, Stroop task-related activation in the parietal cortex and cerebellum increased.Conclusions After improvement of OCD with either fluvoxamine or behavioral therapy, hyperactivation of the frontal lobe related to a symptom-provocative state decreases, and posterior brain activity related to action-monitoring function increases. IS - 8 JF - Biological Psychiatry EP - 910 TI - Brain activation of patients with obsessive-compulsive disorder during neuropsychological and symptom provocation tasks before and after symptom improvement: A functional magnetic resonance imaging study VL - 57 SP - 901 KW - cbt KW - fmri KW - ocd KW - pharmacotherapy KW - psychotherapy KW - treatment AU - Nakao, Tomohiro AU - Nakagawa, Akiko AU - Yoshiura, Takashi AU - Nakatani, Eriko AU - Nabeyama, Maiko AU - Yoshizato, Chika AU - Kudoh, Akiko AU - Tada, Kyoko AU - Yoshioka, Kazuko AU - Kawamoto, Midori AU - Togao, Osamu AU - Kanba, Shigenobu PY - 2005/04/15/ UR - http://www.sciencedirect.com/science/article/B6T4S-4FNCW34-2/2/fb98424add8bd247561e78ad5c142955 ER -