Long-term effects of cognitive behavior therapy on brain activation in spider phobia☆ Export

@article{citeulike:4769500, abstract = {This functional magnetic resonance imaging study investigated long-term effects of cognitive behavior therapy (CBT) in individuals suffering from spider phobia. Ten female patients who had shown positive immediate CBT effects were invited to take part in a 6-month follow-up investigation. Here, the patients, along with eight non-phobic females, were presented with the same pictures depicting spiders, generally disgust-inducing, generally fear-inducing and neutral content, which they had viewed 6 months earlier. Patients' self-report and overt behavior indicated a positive long-term clinical improvement. Related hemodynamic changes included an increase in medial orbitofrontal cortex (OFC) activity. As the medial OFC is involved in emotion-related learning, especially in the representation of positive stimulus-outcome associations, we conclude that the medial OFC effect constitutes the neuronal basis of the lasting positive CBT outcome. Activity to disorder-irrelevant pictures decreased across the sessions in the lateral OFC and in the insula, which most likely reflects general habituation.}, author = {Schienle, Anne and Sch\"{a}fer, Axel and Stark, Rudolf and Vaitl, Dieter}, citeulike-article-id = {4769500}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.pscychresns.2008.11.005}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S092549270800187X}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19321317}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19321317}, day = {15}, doi = {10.1016/j.pscychresns.2008.11.005}, issn = {09254927}, journal = {Psychiatry Research: Neuroimaging}, keywords = {anxiety-disorder, cbt, fmri, follow-up, insula, ofc, picture, spider, spider-phobia, treatment}, month = {May}, number = {2}, pages = {99--102}, posted-at = {2009-06-08 03:47:51}, priority = {4}, title = {Long-term effects of cognitive behavior therapy on brain activation in spider phobia☆}, url = {http://dx.doi.org/10.1016/j.pscychresns.2008.11.005}, volume = {172}, year = {2009} }

TY - JOUR ID - citeulike:4769500 L3 - citeulike-article-id:4769500 N2 - This functional magnetic resonance imaging study investigated long-term effects of cognitive behavior therapy (CBT) in individuals suffering from spider phobia. Ten female patients who had shown positive immediate CBT effects were invited to take part in a 6-month follow-up investigation. Here, the patients, along with eight non-phobic females, were presented with the same pictures depicting spiders, generally disgust-inducing, generally fear-inducing and neutral content, which they had viewed 6 months earlier. Patients' self-report and overt behavior indicated a positive long-term clinical improvement. Related hemodynamic changes included an increase in medial orbitofrontal cortex (OFC) activity. As the medial OFC is involved in emotion-related learning, especially in the representation of positive stimulus-outcome associations, we conclude that the medial OFC effect constitutes the neuronal basis of the lasting positive CBT outcome. Activity to disorder-irrelevant pictures decreased across the sessions in the lateral OFC and in the insula, which most likely reflects general habituation. IS - 2 JF - Psychiatry Research: Neuroimaging SN - 09254927 EP - 102 TI - Long-term effects of cognitive behavior therapy on brain activation in spider phobia☆ VL - 172 SP - 99 KW - anxiety-disorder KW - cbt KW - fmri KW - follow-up KW - insula KW - ofc KW - picture KW - spider KW - spider-phobia KW - treatment AU - Schienle, Anne AU - Schäfer, Axel AU - Stark, Rudolf AU - Vaitl, Dieter PY - 2009/05/15/ UR - http://dx.doi.org/10.1016/j.pscychresns.2008.11.005 ER -