Microarray applications in neuroscience. Export

@article{citeulike:942311, abstract = {Advances in all facets of technology from molecular biology to imaging and computational biology offer unprecedented opportunities for improving our understanding of the brain in health and disease. Oligonucleotide and cDNA microarray analysis, using a variety of "DNA chips," is a recently developed high-throughput technique that allows for tour-de-force analysis of gene expression. We review this powerful technique, developed in genetics laboratories, with reference to applications in neurologic diseases in humans and the use of animal models. The typical microarray experiment is multistaged and includes preparation or purchase of arrays, preparation of target DNA and probe, target DNA hybridization, microarray scanning, and image analysis. The power and pitfalls of this technology are discussed in the context of neuroscience paradigms. Since unprecedented amounts of data are produced from microarray experiments, bioinformatics and modeling expertise are increasingly becoming critical components of this approach.}, address = {Neurogenetics Program, University of California at Los Angeles School of Medicine, Los Angeles, California 90095, USA.}, author = {Luo, Z. and Geschwind, D. H.}, citeulike-article-id = {942311}, citeulike-linkout-0 = {http://dx.doi.org/10.1006/nbdi.2001.0387}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/11300716}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=11300716}, doi = {10.1006/nbdi.2001.0387}, issn = {0969-9961}, journal = {Neurobiol Dis}, keywords = {affymetrix, cdna, experimental\_design, microarray}, month = {April}, number = {2}, pages = {183--193}, posted-at = {2006-11-14 01:09:58}, priority = {2}, title = {Microarray applications in neuroscience.}, url = {http://dx.doi.org/10.1006/nbdi.2001.0387}, volume = {8}, year = {2001} }

TY - JOUR ID - citeulike:942311 L3 - citeulike-article-id:942311 N2 - Advances in all facets of technology from molecular biology to imaging and computational biology offer unprecedented opportunities for improving our understanding of the brain in health and disease. Oligonucleotide and cDNA microarray analysis, using a variety of "DNA chips," is a recently developed high-throughput technique that allows for tour-de-force analysis of gene expression. We review this powerful technique, developed in genetics laboratories, with reference to applications in neurologic diseases in humans and the use of animal models. The typical microarray experiment is multistaged and includes preparation or purchase of arrays, preparation of target DNA and probe, target DNA hybridization, microarray scanning, and image analysis. The power and pitfalls of this technology are discussed in the context of neuroscience paradigms. Since unprecedented amounts of data are produced from microarray experiments, bioinformatics and modeling expertise are increasingly becoming critical components of this approach. IS - 2 JF - Neurobiol Dis SN - 0969-9961 AD - Neurogenetics Program, University of California at Los Angeles School of Medicine, Los Angeles, California 90095, USA. EP - 193 TI - Microarray applications in neuroscience. VL - 8 SP - 183 KW - affymetrix KW - cdna KW - experimental_design KW - microarray AU - Luo, Z AU - Geschwind, DH PY - 2001/04// UR - http://dx.doi.org/10.1006/nbdi.2001.0387 ER -